ZFIN ID: ZDB-GENE-990415-181

Gene Name:nodal-related 2
Gene Symbol: ndr2

Previous Names: Ndr-2, cyclops(1) , cyc-1(1) , cyc(1) , znr1, Znr-1, ndr2

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GENE EXPRESSION:(current status)

All expression data:	32 figure(s) from 27 publications
Wild Type Stages, Structures:	Blastula:Sphere (4.00h-4.33h) to Pharyngula:Prim-5 (24.00h-30.00h)
	axial chorda mesoderm, axial hypoblast ... (all 16)
Curated microarray expression:	GEO  (1)

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MUTANTS AND TARGETED KNOCKDOWNS:

Mutant line(s):   42 genotypes
Allele(s):   b16, b229, c34, c39, hi2718aTg ... (all 14)

Phenotype: (current status)

Data:	13 figures from 7 publications
Observed in:	brain, camera-type eye morphogenesis, convergent extension involved in axis elongation, eye, floor plate ... (all 16)

Knockdown reagent: MO1-ndr2 (1)

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GENE PRODUCTS:

Gene Ontology

Ontology	GO Term
Biological Process	dorsal/ventral pattern formation (more)
Molecular Function	growth factor activity

All GO Terms (19)

Protein Families, Domains and Sites:

InterPro:IPR001111 (1) InterPro:IPR001839 (1) InterPro:IPR015615 (1) InterPro:IPR017948 (1)

PROSITE:PS00250 (1) PROSITE:PS51362 (1)

Pfam:PF00019 (1) Pfam:PF00688 (1)

Gene Product Description

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SEQUENCE INFORMATION:

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_139133 (1)	1514 bp	- Select Tool - ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Polypeptide	UniProtKB:P87358 (1)	501 aa	- Select Tool - ZFIN BLAST Ensembl SIB BLAST
Sequence Clusters	UniGene:18289 (1)
All Sequence Information (8)

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OTHER  ndr2  GENE / MARKER PAGES:

Entrez Gene:30292 (1)

Ensembl(Zv8):ENSDARG00000040299 (1)

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MAPPING INFORMATION:

LG:  12  Details

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ORTHOLOGY:

				Evidence
Species	Symbol	Chromosome (Position)	Accession #	AA	CL
Zebrafish	ndr2	12
Human	NODAL	10 (q22.1)	OMIM:601265 Entrez Gene:4838
Mouse	Nodal	10 (31.50 cM)	MGI:97359 Entrez Gene:18119
Orthology Details

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CITATIONS   (184)