ZFIN ID: ZDB-GENE-980526-89

Gene Name:smoothened homolog (Drosophila)
Gene Symbol: smo

Previous Names: smoothened(1) , wu:fc39h03, smu, CHUNP6862, wu:fb70b01, smoh, slow muscle omitted
Nomenclature History

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GENE EXPRESSION:(current status)

All expression data:	4 figure(s) from 3 publications
Wild Type Stages, Structures:	Pharyngula:Prim-5 (24.00h-30.00h)
	somite
Curated microarray expression:	GEO  (1)

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MUTANTS AND TARGETED KNOCKDOWNS:

Mutant line(s):   37 genotypes
Allele(s):   b577, b641, hi1640Tg, hi229Tg, hi2329bTg ... (all 8)

Phenotype: (current status)

Data:	33 figures from 20 publications
Observed in:	atrium, axon guidance, brain, cardiac muscle cell, cardiac muscle myoblast ... (all 60)

Knockdown reagents: MO1-smo (1) ,   MO2-smo (1) ,   MO3-smo (1) ,   MO4-smo (1)

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GENE PRODUCTS:

Gene Ontology

Ontology	GO Term
Molecular Function	G-protein coupled receptor activity (more)
Biological Process	embryonic camera-type eye development (more)
Cellular Component	cilium (more)

All GO Terms (44)

Protein Families, Domains and Sites:

InterPro:IPR000024 (1) InterPro:IPR000539 (1) InterPro:IPR015526 (1) InterPro:IPR017981 (1) InterPro:IPR020067 (1) InterPro:IPR020068 (1)

PROSITE:PS50038 (1) PROSITE:PS50261 (1)

Pfam:PF01392 (1) Pfam:PF01534 (1)

Gene Product Description

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SEGMENT (CLONE AND PROBE) RELATIONSHIPS:

smo Contained in	[BAC] DKEY-180P18 (1)    (order this)
smo Encodes	[BAC END] zk11h20.sp6 [EST] fb70b01 (1) , fc39h03 (1) [cDNA] zv1 (1) , zv2 (1)    (order this)

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SEQUENCE INFORMATION:

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_131027 (1)	2880 bp	- Select Tool - ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX571796 (1)	130699 bp	- Select Tool - MegaBLAST Ensembl
Polypeptide	UniProtKB:Q5RH73 (1)	822 aa	- Select Tool - ZFIN BLAST Ensembl SIB BLAST
Sequence Clusters	UniGene:114683 (1)
All Sequence Information (15)

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OTHER  smo  GENE / MARKER PAGES:

Entrez Gene:30225 (1)

VEGA:OTTDARG00000007795 (1)

Ensembl(Zv8):ENSDARG00000002952 (1)

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MAPPING INFORMATION:

LG:  22 ,  4    Details

View Map: Merged  Individual Panels

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ORTHOLOGY:

				Evidence
Species	Symbol	Chromosome (Position)	Accession #	AA	CL
Zebrafish	smo	22 ,  4
Human	SMO	7 (q32.3)	OMIM:601500 Entrez Gene:6608
Mouse	Smo	6 (7.20 cM)	MGI:108075 Entrez Gene:319757
Orthology Details

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CITATIONS   (134)