Gene

acvr2ba

ID

ZDB-GENE-980526-549

Name

activin A receptor type 2Ba

Symbol

acvr2ba Nomenclature History

Previous Names

actr2b
actrIIb
acvr2b
wu:fj97d11

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to have activin binding activity and activin-activated receptor activity. Involved in cartilage development; hindbrain development; and neural crest cell migration. Predicted to localize to activin receptor complex. Human ortholog(s) of this gene implicated in visceral heterotaxy. Is expressed in several structures, including blastomere; central nervous system; digestive system; gonad; and oral epithelium. Orthologous to human ACVR2B (activin A receptor type 2B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

17 figures from 6 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:113962 (1 image)
eu356 (5 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Albertson et al., 2005
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With acvr2ba Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
visceral heterotaxy	Alliance	Heterotaxy, visceral, 4, autosomal	613751

Associated With acvr2ba Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Domain	IPR000472	Activin types I and II receptor domain
Domain	IPR000719	Protein kinase domain
Family	IPR000333	Ser/Thr protein kinase, TGFB receptor
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR045860	Snake toxin-like superfamily