Gene
acvr2ba
- ID
- ZDB-GENE-980526-549
- Name
- activin A receptor type 2Ba
- Symbol
- acvr2ba Nomenclature History
- Previous Names
-
- actr2b
- actrIIb
- acvr2b
- wu:fj97d11
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable activin binding activity and activin receptor activity. Acts upstream of or within cartilage development; hindbrain development; and neural crest cell migration. Predicted to be located in membrane. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including blastomere; central nervous system; digestive system; gonad; and oral epithelium. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human ACVR2B (activin A receptor type 2B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:113962 (1 image)
- eu356 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Albertson et al., 2005
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| visceral heterotaxy 4 | Alliance | Heterotaxy, visceral, 4, autosomal | 613751 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Domain | IPR000472 | Activin types I and II receptor domain |
| Domain | IPR000719 | Protein kinase domain |
| Family | IPR000333 | Ser/Thr protein kinase, TGFB receptor |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR045860 | Snake toxin-like superfamily |
Domain Details Per Protein
| Protein | Length | Activin types I and II receptor domain | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Ser/Thr protein kinase, TGFB receptor | Snake toxin-like superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q9YGU4
|
509 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
acvr2ba-201
(1)
|
Ensembl | 1,470 nt | ||
| mRNA |
acvr2ba-202
(1)
|
Ensembl | 1,530 nt | ||
| mRNA |
acvr2ba-203
(1)
|
Ensembl | 674 nt |
Interactions and Pathways
Plasmids