Gene
snap25b
- ID
- ZDB-GENE-980526-392
- Name
- synaptosome associated protein 25b
- Symbol
- snap25b Nomenclature History
- Previous Names
-
- snap25.2 (1)
- wu:fj33h05
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable SNAP receptor activity and syntaxin-1 binding activity. Acts upstream of or within clustering of voltage-gated sodium channels and locomotory behavior. Predicted to be located in cytoplasm and membrane. Predicted to be part of BLOC-1 complex and synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex. Predicted to be active in plasma membrane. Is expressed in head and nervous system. Human ortholog(s) of this gene implicated in Down syndrome and congenital myasthenic syndrome 18. Orthologous to human SNAP25 (synaptosome associated protein 25).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73101 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Moravec et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa7432 | Allele with one point mutation | Unknown | Missense | ENU | |
| sa32130 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa36346 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sbu83 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| tpl27Gt | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-snap25b | Moravec et al., 2016 | |
| MO1-snap25 | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital myasthenic syndrome 18 | Alliance | ?Myasthenic syndrome, congenital, 18 | 616330 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | SNAP-25 domain | SNAP25, N-terminal SNARE motif, chordates | Target SNARE coiled-coil homology domain |
|---|---|---|---|---|---|
| UniProtKB:Q6PC54 | InterPro | 203 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
snap25b-201
(1)
|
Ensembl | 1,582 nt | ||
| mRNA |
snap25b-202
(1)
|
Ensembl | 609 nt | ||
| mRNA |
snap25b-203
(1)
|
Ensembl | 801 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-93A6 | ZFIN Curated Data | |
| Contained in | BAC | CH73-313G15 | ZFIN Curated Data | |
| Contained in | BAC | CH211-271I22 | ZFIN Curated Data | |
| Encodes | EST | fj33h05 | ||
| Encodes | cDNA | MGC:73101 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131434 (1) | 1586 nt | ||
| Genomic | GenBank:BX004854 (1) | 157010 nt | ||
| Polypeptide | UniProtKB:Q6PC54 (1) | 203 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | SNAP25 | 20 | Amino acid sequence comparison (3) Nucleotide sequence comparison (1) Conserved genome location (synteny) (4) | |
| Mouse | Snap25 | 2 | Conserved genome location (synteny) (1) Amino acid sequence comparison (2) Nucleotide sequence comparison (1) | |
| Fruit fly | Snap25 | 3L | Nucleotide sequence comparison (1) Amino acid sequence comparison (1) |
- Whyte-Fagundes, P., Taskina, D., Safarian, N., Zoidl, C., Carlen, P.L., Donaldson, L.W., Zoidl, G.R. (2022) Panx1 channels promote both anti- and pro-seizure-like activities in the zebrafish via p2rx7 receptors and ATP signaling. Communications biology. 5:472
- Zhong, Y., Zhang, N., Zhao, F., Chang, S., Chen, W., Cao, Q., Sun, L., Wang, Y., Gong, Z., Lu, L., Liu, D., Yang, L. (2022) RBFOX1 and Working Memory: From Genome to Transcriptome Revealed Posttranscriptional Mechanism Separate From Attention-Deficit/Hyperactivity Disorder. Biological psychiatry global open science. 3:104210521042-1052
- Daniel, J.G., Panizzi, J.R. (2019) Spatiotemporal expression profile of embryonic and adult ankyrin repeat and EF-hand domain containing protein 1-encoding genes ankef1a and ankef1b in zebrafish. Gene expression patterns : GEP. 34:119069
- Mastrodonato, V., Beznoussenko, G., Mironov, A., Ferrari, L., Deflorian, G., Vaccari, T. (2019) A genetic model of CEDNIK syndrome in zebrafish highlights the role of the SNARE protein Snap29 in neuromotor and epidermal development. Scientific Reports. 9:1211
- Monestime, C.M., Taibi, A., Gates, K.P., Jiang, K., Sirotkin, H.I. (2019) CoRest1 regulates neurogenesis in a stage-dependent manner. Developmental Dynamics : an official publication of the American Association of Anatomists. 248(10):918-930
- Zhao, G., Wang, Z., Xu, L., Xia, C.X., Liu, J.X. (2019) Silver nanoparticles induce abnormal touch responses by damaging neural circuits in zebrafish embryos. Chemosphere. 229:169-180
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Fontenas, L., De Santis, F., Di Donato, V., Degerny, C., Chambraud, B., Del Bene, F., Tawk, M. (2016) Neuronal Ndrg4 Is Essential for Nodes of Ranvier Organization in Zebrafish. PLoS Genetics. 12:e1006459
- Moravec, C.E., Samuel, J., Weng, W., Wood, I.C., Sirotkin, H.I. (2016) Maternal Rest/Nrsf Regulates Zebrafish Behavior through snap25a/b. The Journal of neuroscience : the official journal of the Society for Neuroscience. 36:9407-19
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