Gene
acvr2aa
- ID
- ZDB-GENE-980526-227
- Name
- activin A receptor type 2Aa
- Symbol
- acvr2aa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable activin binding activity and activin receptor activity. Acts upstream of or within cartilage development; hindbrain development; and neural crest cell migration. Predicted to be located in membrane. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including blastoderm; blastomere; gut; oral region; and ovarian follicle. Human ortholog(s) of this gene implicated in Lynch syndrome and colon cancer. Orthologous to human ACVR2A (activin A receptor type 2A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Albertson et al., 2005
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Domain | IPR000472 | Activin types I and II receptor domain |
| Domain | IPR000719 | Protein kinase domain |
| Family | IPR000333 | Ser/Thr protein kinase, TGFB receptor |
| Family | IPR017194 | Transforming growth factor-beta receptor, type II |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR045860 | Snake toxin-like superfamily |
Domain Details Per Protein
| Protein | Length | Activin types I and II receptor domain | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Ser/Thr protein kinase, TGFB receptor | Snake toxin-like superfamily | Transforming growth factor-beta receptor, type II |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PS26
|
522 | |||||||
|
UniProtKB:A0A8M9QFD6
|
538 | |||||||
|
UniProtKB:A0A8M2BFL8
|
530 | |||||||
|
UniProtKB:F1QG01
|
514 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
acvr2aa-201
(1)
|
Ensembl | 3,746 nt | ||
| mRNA |
acvr2aa-202
(1)
|
Ensembl | 1,617 nt | ||
| mRNA |
acvr2aa-203
(1)
|
Ensembl | 5,124 nt | ||
| ncRNA |
acvr2aa-002
(1)
|
Ensembl | 539 nt |
Interactions and Pathways
No data available
Plasmids
No data available