Research
General Information
ZIRC
ZFIN: Gene: ptc2
ZFIN ID: ZDB-GENE-980526-196

Gene Name:patched 2
Gene Symbol: ptc2
Previous Names: lep, leprechaun
Nomenclature History


GENE EXPRESSION:(current status)
All expression data: 17 figure(s) from 10 publications
Directly submitted expression data: 6 figure(s) (7 images) from Thisse et al., 2005 [eu578]
Wild Type Stages, Structures: Segmentation:10-13 somites (14.00h-16.00h) to Adult (90d-730d, breeding adult)
  basibranchial, brain ... (all 13)
Curated microarray expression: GEO  (1)

MUTANTS AND TARGETED KNOCKDOWNS:
Mutant line(s):   11 genotypes
Allele(s):   tj222, tq236
Phenotype: (current status)
  Data: 6 figures from 4 publications
  Observed in: anatomical system, dorsolateral septum, fast muscle cell, inner ear, lens ... (all 10)
Knockdown reagents: MO1-ptc2 (1) ,   MO2-ptc2 (1)

GENE PRODUCTS:

Gene Ontology
Ontology GO Term
Biological Process cardioblast differentiation (more)
Cellular Component integral to membrane (more)
Molecular Function hedgehog receptor activity
All GO Terms (6)

Protein Families, Domains and Sites:
  • InterPro:IPR000731 (1)
  • InterPro:IPR003392 (1)
  • InterPro:IPR004766 (1)
  • PROSITE:PS50156 (1)
  • Pfam:PF02460 (1)
  • Loading Transcript Data...

    SEGMENT (CLONE AND PROBE) RELATIONSHIPS:
    ptc2 Contained in [BAC] DKEY-72L19 (1)    (order this) , DKEY-185L9 (1)    (order this)
    ptc2 Encodes [EST] eu578 (1)

    SEQUENCE INFORMATION:
    Type Accession # Length (bp/aa) Analysis
    RNA GenBank:AJ007742 3732 bp
    Genomic GenBank:CR847548 (1) 249728 bp
    Polypeptide UniProtKB:B0UXP5 (1) 1354 aa
    Sequence Clusters UniGene:116176 (1)
    All Sequence Information (11)

    OTHER  ptc2  GENE / MARKER PAGES:

  • Entrez Gene:30189 (1)
  • VEGA:OTTDARG00000020299 (1)
  • Ensembl(Zv8):ENSDARG00000016404 (1)

  • MAPPING INFORMATION:
      LG:  8    Details   View Map: Merged  Individual Panels

    ORTHOLOGY:
      Evidence
    Species Symbol Chromosome (Position) Accession # AA CL
    Zebrafish ptc2  8
    Human PTCH1  9 (q22.3)
  • OMIM:601309
  • Entrez Gene:5727
  • Mouse Ptch1  13 (36.00 cM)
  • MGI:105373
  • Entrez Gene:19206
  • Orthology Details

    CITATIONS   (45)