ZFIN ID: ZDB-GENE-980526-166

Gene Name:sonic hedgehog a
Gene Symbol: shha

Previous Names: sonic you, vertebrate hedgehog homolog(1) , sonic-you(1) , shh, fc83d08, vhh1(1) , syu, wu:fc83d08(1)
Nomenclature History

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GENE EXPRESSION:(current status)

All expression data:	234 figure(s) from 181 publications
Wild Type Stages, Structures:	Blastula:30%-epiboly (4.66h-5.25h) to Adult (90d-730d, breeding adult)
	axial mesoderm, axis ... (all 67)
Curated microarray expression:	GEO  (1)

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MUTANTS AND TARGETED KNOCKDOWNS:

Mutant line(s):   31 genotypes
Allele(s):   b240, t4, tbq70, tbx392, tq252 ... (all 6)

Phenotype: (current status)

Data:	10 figures from 7 publications
Observed in:	anatomical system, eye, fin, floor plate, heart ... (all 23)

Knockdown reagents: MO1-shha (1) ,   MO2-shha (1) ,   MO3-shha (1)

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GENE PRODUCTS:

Gene Ontology

Ontology	GO Term
Biological Process	adenohypophysis development (more)
Cellular Component	extracellular region (more)
Molecular Function	hydrolase activity (more)

All GO Terms (55)

Protein Families, Domains and Sites:

InterPro:IPR000320 (1) InterPro:IPR001657 (1) InterPro:IPR001767 (1) InterPro:IPR003586 (1) InterPro:IPR003587 (1) InterPro:IPR006141 (1) InterPro:IPR009045 (1)

PROSITE:PS50817 (1)

Pfam:PF01079 (1) Pfam:PF01085 (1)

Gene Product Description

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CONSTRUCTS WITH SEQUENCE FROM shha:

Tg(-2.7shha:GFP), Tg(-2.4shha-C:GFP), Tg(-2.4shha-BC:GFP), Tg(-2.4shha-E1:GFP) ... (all 12)

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SEGMENT (CLONE AND PROBE) RELATIONSHIPS:

shha Contained in	[BAC] CH211-150E22 (1)    (order this)
shha Encodes	[EST] fc83d08 [cDNA] MGC:194075 (1)    (order this)

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SEQUENCE INFORMATION:

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_131063 (1)	2600 bp	- Select Tool - ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:AL929206 (1)	153126 bp	- Select Tool - MegaBLAST Ensembl
Polypeptide	UniProtKB:Q1MTB5 (1)	418 aa	- Select Tool - ZFIN BLAST Ensembl SIB BLAST
Sequence Clusters	UniGene:36074 (1)
All Sequence Information (22)

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OTHER  shha  GENE / MARKER PAGES:

Entrez Gene:30269 (1)

VEGA:OTTDARG00000018404 (1)

Ensembl(Zv8):ENSDARG00000068567 (1)

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MAPPING INFORMATION:

LG:  7    Details

View Map: Merged  Individual Panels

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ORTHOLOGY:

				Evidence
Species	Symbol	Chromosome (Position)	Accession #	AA	CL
Zebrafish	shha	7
Human	SHH	7 (q36)	OMIM:600725 Entrez Gene:6469
Mouse	Shh	5 (16.00 cM)	MGI:98297 Entrez Gene:20423
Orthology Details

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CITATIONS   (416)