Gene

mocs1

ID
ZDB-GENE-130215-1
Name
molybdenum cofactor synthesis 1
Symbol
mocs1 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to enable GTP 3',8'-cyclase activity and cyclic pyranopterin monophosphate synthase activity. Predicted to be involved in Mo-molybdopterin cofactor biosynthetic process. Human ortholog(s) of this gene implicated in molybdenum cofactor deficiency type A. Orthologous to human MOCS1 (molybdenum cofactor synthesis 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mocs1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
molybdenum cofactor deficiency type A Alliance Molybdenum cofactor deficiency A 252150
Associated With mocs1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR000385 MoaA/NifB/PqqE, iron-sulphur binding, conserved site
Domain IPR002820 Molybdopterin cofactor biosynthesis C (MoaC) domain
Domain IPR006638 Elp3/MiaA/NifB-like, radical SAM core domain
Domain IPR007197 Radical SAM
Domain IPR010505 Molybdenum cofactor biosynthesis protein A-like, twitch domain
Family IPR013483 Molybdenum cofactor biosynthesis protein A
Family IPR023045 Molybdenum cofactor biosynthesis C
Family IPR047594 Molybdenum cofactor biosynthesis C, bacteria/eukaryotes
Family IPR050105 Molybdenum cofactor biosynthesis MoaA/MoaC
Homologous_superfamily IPR013785 Aldolase-type TIM barrel
Homologous_superfamily IPR036522 Molybdopterin cofactor biosynthesis C (MoaC) domain superfamily
Domain Details Per Protein
Protein Length Aldolase-type TIM barrel Elp3/MiaA/NifB-like, radical SAM core domain MoaA/NifB/PqqE, iron-sulphur binding, conserved site Molybdenum cofactor biosynthesis C Molybdenum cofactor biosynthesis C, bacteria/eukaryotes Molybdenum cofactor biosynthesis MoaA/MoaC Molybdenum cofactor biosynthesis protein A Molybdenum cofactor biosynthesis protein A-like, twitch domain Molybdopterin cofactor biosynthesis C (MoaC) domain Molybdopterin cofactor biosynthesis C (MoaC) domain superfamily Radical SAM
UniProtKB:A0A8M3AJ79
InterPro
734
UniProtKB:F1R905
InterPro
402
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA mocs1-201 (1)
Ensembl
Ensembl 2,484 nt
ZFIN BLAST
mRNA mocs1-202 (1)
Ensembl
Ensembl 2,185 nt
ZFIN BLAST
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations
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