Gene
kcna4
- ID
- ZDB-GENE-121127-2
- Name
- potassium voltage-gated channel, shaker-related subfamily, member 4
- Symbol
- kcna4 Nomenclature History
- Previous Names
-
- knca4
- zmp:0000001194
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable potassium ion binding activity and voltage-gated potassium channel activity. Predicted to act upstream of or within potassium ion transmembrane transport and protein homooligomerization. Predicted to be located in cell projection and plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Is expressed in heart. Orthologous to human KCNA4 (potassium voltage-gated channel subfamily A member 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Gou et al., 2020
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Microcephaly, cataracts, impaired intellectual development, and dystonia with abnormal striatum | 618284 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000210 | BTB/POZ domain |
| Domain | IPR003131 | Potassium channel tetramerisation-type BTB domain |
| Domain | IPR005821 | Ion transport domain |
| Domain | IPR012897 | Potassium channel, voltage dependent, Kv1.4, tandem inactivation domain |
| Family | IPR003968 | Potassium channel, voltage dependent, Kv |
| Family | IPR003972 | Potassium channel, voltage dependent, Kv1 |
| Family | IPR020467 | Potassium channel, voltage dependent, Kv1.4 |
| Family | IPR028325 | Voltage-gated potassium channel |
| Homologous_superfamily | IPR011333 | SKP1/BTB/POZ domain superfamily |
| Homologous_superfamily | IPR027359 | Voltage-dependent channel domain superfamily |
| Homologous_superfamily | IPR037065 | Potassium channel, voltage dependent, Kv1.4, tandem inactivation domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | BTB/POZ domain | Ion transport domain | Potassium channel tetramerisation-type BTB domain | Potassium channel, voltage dependent, Kv | Potassium channel, voltage dependent, Kv1 | Potassium channel, voltage dependent, Kv1.4 | Potassium channel, voltage dependent, Kv1.4, tandem inactivation domain | Potassium channel, voltage dependent, Kv1.4, tandem inactivation domain superfamily | SKP1/BTB/POZ domain superfamily | Voltage-dependent channel domain superfamily | Voltage-gated potassium channel |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1Q929 | InterPro | 667 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance