Gene

angpt2a

ID

ZDB-GENE-121101-1

Name

angiopoietin 2a

Symbol

angpt2a Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to enable receptor tyrosine kinase binding activity. Predicted to be involved in Tie signaling pathway. Predicted to act upstream of or within angiogenesis and cell differentiation. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human ANGPT2 (angiopoietin 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Takada et al., 2017

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With angpt2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Lymphatic malformation 10	619369

Associated With angpt2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020837	Fibrinogen, conserved site
Domain	IPR002181	Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
Family	IPR050373	Fibrinogen C-terminal domain-containing protein
Homologous_superfamily	IPR014716	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
Homologous_superfamily	IPR036056	Fibrinogen-like, C-terminal