Gene
tnfrsf11a
- ID
- ZDB-GENE-120910-2
- Name
- tumor necrosis factor receptor superfamily, member 11a, NFKB activator
- Symbol
- tnfrsf11a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable cytokine binding activity and tumor necrosis factor receptor activity. Predicted to be involved in several processes, including multinuclear osteoclast differentiation; positive regulation of bone resorption; and tumor necrosis factor-mediated signaling pathway. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in bone development disease and bone remodeling disease (multiple). Orthologous to human TNFRSF11A (TNF receptor superfamily member 11a).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive osteopetrosis 7 | Alliance | Osteopetrosis, autosomal recessive 7 | 612301 |
| familial expansile osteolysis | Alliance | Osteolysis, familial expansile | 174810 |
| Paget's disease of bone 2 | Alliance | {Paget disease of bone 2, early-onset} | 602080 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | TNFR/NGFR cysteine-rich region | Tumor necrosis factor receptor superfamily member 11A |
|---|---|---|---|
|
UniProtKB:A0A8M9PE80
|
497 | ||
|
UniProtKB:A0A8M3AVZ3
|
497 | ||
|
UniProtKB:E7F027
|
574 | ||
|
UniProtKB:A0A8M9P635
|
506 | ||
|
UniProtKB:A0A8M9Q403
|
506 | ||
|
UniProtKB:A0A8M9PQZ0
|
236 | ||
|
UniProtKB:A0A8M9Q849
|
574 | ||
|
UniProtKB:A0A8M3ANI1
|
236 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tnfrsf11a-201
(1)
|
Ensembl | 3,624 nt |
Interactions and Pathways
No data available
Plasmids
No data available