Gene
nampt1
- ID
- ZDB-GENE-110420-1
- Name
- nicotinamide phosphoribosyltransferase 1
- Symbol
- nampt1 Nomenclature History
- Previous Names
-
- nampt
- nampta (1)
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to have cytokine activity; nicotinamide phosphoribosyltransferase activity; and nicotinate-nucleotide diphosphorylase (carboxylating) activity. Predicted to be involved in NAD biosynthetic process and circadian regulation of gene expression. Predicted to localize to cytoplasm; extracellular space; and nucleus. Human ortholog(s) of this gene implicated in transient cerebral ischemia. Orthologous to human NAMPT (nicotinamide phosphoribosyltransferase).
- Genome Resources
- Note
-
This gene name was updated because the phylogenetic tree indicates this was the result of a duplication event PRIOR to the divergence of ray- and lobe-fin fishes and not the teleost WGD
- Comparative Information
-
- All Expression Data
- 1 figure from Ratnayake et al., 2021
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Morishima et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR041525 | Nicotinate/nicotinamide phosphoribosyltransferase |
| Domain | IPR041529 | Nicotinamide phosphoribosyltransferase, N-terminal domain |
| Family | IPR016471 | Nicotinamide phosphoribosyl transferase |
| Homologous_superfamily | IPR013785 | Aldolase-type TIM barrel |
| Homologous_superfamily | IPR036068 | Nicotinate phosphoribosyltransferase-like, C-terminal |
Domain Details Per Protein
| Protein | Length | Aldolase-type TIM barrel | Nicotinamide phosphoribosyl transferase | Nicotinamide phosphoribosyltransferase, N-terminal domain | Nicotinate/nicotinamide phosphoribosyltransferase | Nicotinate phosphoribosyltransferase-like, C-terminal |
|---|---|---|---|---|---|---|
|
UniProtKB:E7F8T6
|
493 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nampta-201
(1)
|
Ensembl | 1,722 nt |
Interactions and Pathways
No data available
Plasmids
No data available