Gene

c4b

ID

ZDB-GENE-100805-2

Name

complement C4B (Chido/Rodgers blood group)

Symbol

c4b Nomenclature History

Previous Names

c4-2 (1)
c4bl
si:dkey-8k3.2

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have endopeptidase inhibitor activity. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in autistic disorder; autoimmune hypersensitivity disease (multiple); complement component 4b deficiency; renal cell carcinoma; and rheumatoid arthritis. Orthologous to human C4B (complement C4B (Chido blood group)).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With c4b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
complement component 4b deficiency	Alliance	C4B deficiency	614379

Associated With c4b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019742	Alpha-2-macroglobulin, conserved site
Conserved_site	IPR047565	Alpha-macroglobulin-like, thiol-ester bond-forming region
Domain	IPR000020	Anaphylatoxin/fibulin
Domain	IPR001134	Netrin domain
Domain	IPR001599	Alpha-2-macroglobulin
Domain	IPR002890	Macroglobulin domain
Domain	IPR009048	Alpha-macroglobulin, receptor-binding
Domain	IPR011625	Alpha-2-macroglobulin, bait region domain
Domain	IPR011626	Alpha-macroglobulin-like, TED domain
Domain	IPR018933	Netrin module, non-TIMP type
Domain	IPR040839	Macroglobulin domain MG4
Domain	IPR041555	Macroglobulin domain MG3
Homologous_superfamily	IPR008930	Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
Homologous_superfamily	IPR008964	Invasin/intimin cell-adhesion fragments
Homologous_superfamily	IPR008993	Tissue inhibitor of metalloproteinases-like, OB-fold
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR018081	Anaphylatoxin, complement system
Homologous_superfamily	IPR036595	Alpha-macroglobulin, receptor-binding domain superfamily

Domain Details Per Protein

Protein	Length	Alpha-2-macroglobulin	Alpha-2-macroglobulin, bait region domain	Alpha-2-macroglobulin, conserved site	Alpha-macroglobulin-like, TED domain	Alpha-macroglobulin-like, thiol-ester bond-forming region	Alpha-macroglobulin, receptor-binding	Alpha-macroglobulin, receptor-binding domain superfamily	Anaphylatoxin, complement system	Anaphylatoxin/fibulin	Immunoglobulin-like fold	Invasin/intimin cell-adhesion fragments	Macroglobulin domain	Macroglobulin domain MG3	Macroglobulin domain MG4	Netrin domain	Netrin module, non-TIMP type	Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid	Tissue inhibitor of metalloproteinases-like, OB-fold
UniProtKB:A0A8M1Q1D0 InterPro	1717

Transcripts

Genome Browsers

UCSC

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	si:dkey-8k3.2-201 (1) Ensembl	Havana	866 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	si:dkey-8k3.2-202 (1) Ensembl	Havana	5339 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	ottdart00000052435 (1) Ensembl	Havana	760 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations