Gene
card11
- ID
- ZDB-GENE-100219-1
- Name
- caspase recruitment domain family, member 11
- Symbol
- card11 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to have CARD domain binding activity. Predicted to be involved in positive regulation of NF-kappaB transcription factor activity and regulation of apoptotic process. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in diffuse large B-cell lymphoma and primary immunodeficiency disease. Is expressed in gill; intestine; kidney; spleen; and unfertilized egg. Orthologous to human CARD11 (caspase recruitment domain family member 11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Chang et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 11A | Alliance | Immunodeficiency 11A | 615206 |
| immunodeficiency 11B | Alliance | Immunodeficiency 11B with atopic dermatitis | 617638 |
| B-cell expansion with NFKB and T-cell anergy | 616452 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | CARD domain | Death-like domain superfamily | PDZ superfamily | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M6YZ97
|
1122 | ||||
|
UniProtKB:A0A8M3B168
|
1125 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
card11-202
(1)
|
Havana | 4308 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance