Gene
vav2
- ID
- ZDB-GENE-091204-420
- Name
- vav 2 guanine nucleotide exchange factor
- Symbol
- vav2 Nomenclature History
- Previous Names
-
- si:dkeyp-116h7.3
- wan
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to have guanyl-nucleotide exchange factor activity and metal ion binding activity. Predicted to be involved in intracellular signal transduction. Predicted to localize to integral component of membrane. Is expressed in heart. Orthologous to human VAV2 (vav guanine nucleotide exchange factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001331 | Guanine-nucleotide dissociation stimulator, CDC24, conserved site |
| Domain | IPR000219 | Dbl homology (DH) domain |
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR001715 | Calponin homology domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| Domain | IPR022613 | Calmodulin-regulated spectrin-associated protein-like, Calponin-homology domain |
| Domain | IPR035732 | VAV2 protein, second SH3 domain |
| Domain | IPR035880 | VAV2, SH2 domain |
| Domain | IPR037832 | Vav, PH domain |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR035899 | Dbl homology (DH) domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
| Homologous_superfamily | IPR036872 | CH domain superfamily |
Domain Details Per Protein
| Protein | Length | Calmodulin-regulated spectrin-associated protein-like, Calponin-homology domain | Calponin homology domain | CH domain superfamily | Dbl homology (DH) domain | Dbl homology (DH) domain superfamily | Guanine-nucleotide dissociation stimulator, CDC24, conserved site | PH-like domain superfamily | Pleckstrin homology domain | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | SH2 domain | SH2 domain superfamily | SH3 domain | SH3-like domain superfamily | VAV2 protein, second SH3 domain | VAV2, SH2 domain | Vav, PH domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PR05
|
890 | ||||||||||||||||
|
UniProtKB:A0A8M3ALG5
|
879 | ||||||||||||||||
|
UniProtKB:A0A8M3AM66
|
870 | ||||||||||||||||
|
UniProtKB:A0A8M9P3P6
|
886 | ||||||||||||||||
|
UniProtKB:A0A8M9PPX7
|
819 | ||||||||||||||||
|
UniProtKB:A0A8M9PUI9
|
891 | ||||||||||||||||
|
UniProtKB:A0A8M6YV87
|
880 | ||||||||||||||||
|
UniProtKB:A0A8M3ATW1
|
841 | ||||||||||||||||
|
UniProtKB:A0A286Y8W8
|
875 | ||||||||||||||||
|
UniProtKB:A0A8M9PIU4
|
862 | ||||||||||||||||
|
UniProtKB:A0A8M3AWV3
|
869 |
Interactions and Pathways
No data available
Plasmids
No data available