Gene
gabra3
- ID
- ZDB-GENE-091204-365
- Name
- gamma-aminobutyric acid type A receptor subunit alpha3
- Symbol
- gabra3 Nomenclature History
- Previous Names
-
- si:ch211-113k9.1
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable GABA-gated chloride ion channel activity. Predicted to contribute to GABA-A receptor activity; benzodiazepine receptor activity; and chloride channel activity. Acts upstream of or within thigmotaxis. Predicted to be located in postsynaptic membrane. Predicted to be part of GABA-A receptor complex. Predicted to be active in dendrite membrane and postsynapse. Is expressed in brain; eye; and spinal cord. Human ortholog(s) of this gene implicated in bipolar disorder and multiple sclerosis. Orthologous to human GABRA3 (gamma-aminobutyric acid type A receptor subunit alpha3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Barnaby et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-gabra3 | Barnaby et al., 2022 | |
| CRISPR2-gabra3 | Barnaby et al., 2022 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Epilepsy, X-linked 2, with or without impaired intellectual development and dysmorphic features | 301091 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018000 | Neurotransmitter-gated ion-channel, conserved site |
| Domain | IPR006029 | Neurotransmitter-gated ion-channel transmembrane domain |
| Domain | IPR006202 | Neurotransmitter-gated ion-channel ligand-binding domain |
| Family | IPR001390 | Gamma-aminobutyric-acid A receptor, alpha subunit |
| Family | IPR006028 | Gamma-aminobutyric acid A receptor/Glycine receptor alpha |
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Domain Details Per Protein
| Protein | Length | Gamma-aminobutyric-acid A receptor, alpha subunit | Gamma-aminobutyric acid A receptor/Glycine receptor alpha | Neuronal acetylcholine receptor | Neurotransmitter-gated ion-channel | Neurotransmitter-gated ion-channel, conserved site | Neurotransmitter-gated ion-channel ligand-binding domain | Neurotransmitter-gated ion-channel ligand-binding domain superfamily | Neurotransmitter-gated ion-channel transmembrane domain | Neurotransmitter-gated ion-channel transmembrane domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PV35
|
305 | |||||||||
|
UniProtKB:A0A8M9PJD5
|
306 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gabra3-201
(1)
|
Ensembl | 374 nt | ||
| mRNA |
gabra3-202
(1)
|
Ensembl | 834 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-113K9 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-287G19 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021469255 (1) | 1182 nt | ||
| Genomic | GenBank:BX899180 (2) | 182150 nt | ||
| Polypeptide | UniProtKB:A0A8M9PJD5 (1) | 306 aa |
- Reyes-Nava, N.G., Paz, D., Pinales, B.E., Perez, I., Gil, C.B., Gonzales, A.V., Grajeda, B.I., Estevao, I.L., Ellis, C.C., Castro, V.L., Quintana, A.M. (2024) Characterization of the zebrafish gabra1sa43718/sa43718 germline loss of function allele confirms a function for Gabra1 in motility and nervous system development. Differentiation; research in biological diversity. 138:100790100790
- Simonian, R., Pannia, E., Hammoud, R., Noche, R.R., Cui, X., Kranenburg, E., Kubant, R., Ashcraft, P., Wasek, B., Bottiglieri, T., Dowling, J.J., Anderson, G.H. (2023) Methylenetetrahydrofolate reductase deficiency and high dose FA supplementation disrupt embryonic development of energy balance and metabolic homeostasis in zebrafish. Human molecular genetics. 32(9):1575-1588
- Wang, Y., Liu, C., Deng, J., Xu, Q., Lin, J., Li, H., Hu, M., Hu, C., Li, Q., Xu, X. (2023) Behavioral and Sensory Deficits Associated with Dysfunction of GABAergic System in a Novel shank2-Deficient Zebrafish Model. International Journal of Molecular Sciences. 24(3):
- Barnaby, W., Dorman Barclay, H.E., Nagarkar, A., Perkins, M., Teicher, G., Trapani, J.G., Downes, G.B. (2022) GABAA α Subunit Control of Hyperactive Behavior in Developing Zebrafish. Genetics. 220(4):
- Sadamitsu, K., Shigemitsu, L., Suzuki, M., Ito, D., Kashima, M., Hirata, H. (2021) Characterization of zebrafish GABAA receptor subunits. Scientific Reports. 11:6242
- Reyes-Nava, N., Yu, H.C., Coughlin, C.R., Shaikh, T.H., Quintana, A.M. (2020) Abnormal expression of GABAA receptor sub-units and hypomotility upon loss of gabra1 in zebrafish. Biology Open. 9(4):
- Vossen, L.E., Cerveny, D., Österkrans, M., Thörnqvist, P.O., Jutfelt, F., Fick, J., Brodin, T., Winberg, S. (2020) Chronic exposure to oxazepam pollution produces tolerance to anxiolytic effects in zebrafish (Danio rerio). Environmental science & technology. 54(3):1760-1769
- Cao, Y., Yan, H., Yu, G., Su, R. (2019) Flumazenil-insensitive benzodiazepine binding sites in GABAA receptors contribute to benzodiazepine-induced immobility in zebrafish larvae. Life sciences. 239:117033
- Monesson-Olson, B., McClain, J.J., Case, A.E., Dorman, H.E., Turkewitz, D.R., Steiner, A.B., Downes, G.B. (2018) Expression of the eight GABAA receptor α subunits in the developing zebrafish central nervous system. PLoS One. 13:e0196083
- Cocco, A., Carolina Rönnberg, A.M., Jin, Z., André, G.I., Vossen, L.E., Bhandage, A.K., Thörnqvist, P.O., Birnir, B., Winberg, S. (2017) Characterisation of the γ-aminobutyric acid signalling system in the zebrafish (Danio rerio Hamilton) central nervous system by reverse transcription quantitative polymerase chain reaction. Neuroscience. 343:300-321
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