Gene

ltbp1

ID

ZDB-GENE-091202-8

Name

latent transforming growth factor beta binding protein 1

Symbol

ltbp1 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to have calcium ion binding activity. Orthologous to human LTBP1 (latent transforming growth factor beta binding protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ltbp1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Cutis laxa, autosomal recessive, type IIE	619451

Associated With ltbp1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR013032	EGF-like, conserved site
Conserved_site	IPR018097	EGF-like calcium-binding, conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR017878	TB domain
Domain	IPR049883	NOTCH1 EGF-like calcium-binding domain
Family	IPR050751	Extracellular matrix structural protein
Family	IPR051145	Growth Arrest-Specific/Sex Hormone-Binding/Vitamin K-Dependent
Family	IPR052080	von Willebrand factor C/EGF & Fibrillin
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR036773	TGF-beta binding (TB) domain superfamily
PTM	IPR000152	EGF-type aspartate/asparagine hydroxylation site

Domain Details Per Protein

Protein	Length	EGF-like calcium-binding, conserved site	EGF-like calcium-binding domain	EGF-like, conserved site	EGF-like domain	EGF-type aspartate/asparagine hydroxylation site	Extracellular matrix structural protein	Growth Arrest-Specific/Sex Hormone-Binding/Vitamin K-Dependent	Growth factor receptor cysteine-rich domain superfamily	NOTCH1 EGF-like calcium-binding domain	TB domain	TGF-beta binding (TB) domain superfamily	von Willebrand factor C/EGF & Fibrillin
UniProtKB:A0A8M6Z1R3 InterPro	1471
UniProtKB:A0A8M9Q6K8 InterPro	1384
UniProtKB:A0A8M9PVF2 InterPro	1385
UniProtKB:A0A8M9PSN6 InterPro	1232
UniProtKB:A0A8M6Z2F6 InterPro	1527
UniProtKB:A0A8M9PYR1 InterPro	1176
UniProtKB:A0A8M6YTB9 InterPro	1526
UniProtKB:A0A8M9Q2F9 InterPro	1329

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	ltbp1-201 (1) Ensembl	Ensembl		4,287 nt	Select Tool ZFIN BLAST
mRNA	ltbp1-202 (1) Ensembl	Ensembl		4,056 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations