Gene
pde1cb
- ID
- ZDB-GENE-090902-2
- Name
- phosphodiesterase 1C, calmodulin-dependent b
- Symbol
- pde1cb Nomenclature History
- Previous Names
-
- pde1c
- zmp:0000001045
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity and calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity. Predicted to be involved in cAMP-mediated signaling. Predicted to act upstream of or within signal transduction. Predicted to be active in neuronal cell body. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 74. Orthologous to human PDE1C (phosphodiesterase 1C).
- Genome Resources
-
- Alliance (1)
- Gene:100536162 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 74 | Alliance | ?Deafness, autosomal dominant 74 | 618140 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR023174 | 3'5'-cyclic nucleotide phosphodiesterase, conserved site |
| Domain | IPR002073 | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain |
| Domain | IPR003607 | HD/PDEase domain |
| Domain | IPR013706 | 3'5'-cyclic nucleotide phosphodiesterase N-terminal |
| Family | IPR023088 | 3'5'-cyclic nucleotide phosphodiesterase |
| Homologous_superfamily | IPR036971 | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily |
Domain Details Per Protein
| Protein | Length | 3'5'-cyclic nucleotide phosphodiesterase | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily | 3'5'-cyclic nucleotide phosphodiesterase, conserved site | 3'5'-cyclic nucleotide phosphodiesterase N-terminal | HD/PDEase domain |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M1RN98
|
603 | ||||||
|
UniProtKB:A0A8M6YUN9
|
698 | ||||||
|
UniProtKB:A0A8M3B7Y8
|
679 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance