Gene
fgd5a
- ID
- ZDB-GENE-090428-3
- Name
- FYVE, RhoGEF and PH domain containing 5a
- Symbol
- fgd5a Nomenclature History
- Previous Names
-
- fgd5
- zmp:0000000940
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Is expressed in blood island; cranial vasculature; and trunk vasculature. Orthologous to human FGD5 (FYVE, RhoGEF and PH domain containing 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa11066 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14523 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16294 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21880 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa35058 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35059 | Allele with one point mutation | Unknown | Unknown | ENU | |
| um134 | Allele with one deletion | Unknown | Frameshift, Premature Stop | zinc finger nuclease |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-fgd5a | N/A | (2) |
| TALEN1-fgd5a | Xiao et al., 2013 | |
| TALEN2-fgd5a | Xiao et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Dbl homology (DH) domain superfamily | FYVE, RhoGEF and PH domain-containing | FYVE zinc finger | PH-like domain superfamily | Pleckstrin homology domain | Zinc finger, FYVE-related | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QLY3 | InterPro | 1473 | |||||||
| UniProtKB:A0A8M2B1Z4 | InterPro | 1464 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-14H17 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021479795 (1) | 8700 nt | ||
| Genomic | GenBank:BX005175 (1) | 234851 nt | ||
| Polypeptide | UniProtKB:A0A8M9QLY3 (1) | 1473 aa |
- Baek, J.I., Kwon, S.H., Zuo, X., Kwon, S.Y., Kim, S.H., Lipschutz, J.H. (2016) Dynamin Binding Protein (Tuba) deficiency inhibits ciliogenesis and nephrogenesis in vitro and in vivo. The Journal of biological chemistry. 291(16):8632-43
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kok, F.O., Shin, M., Ni, C., Gupta, A., Grosse, A.S., van Impel, A., Kirchmaier, B.C., Peterson-Maduro, J., Kourkoulis, G., Male, I., DeSantis, D.F., Sheppard-Tindell, S., Ebarasi, L., Betsholtz, C., Schulte-Merker, S., Wolfe, S.A., Lawson, N.D. (2015) Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish. Developmental Cell. 32(1):97-108
- Wakayama, Y., Fukuhara, S., Ando, K., Matsuda, M., Mochizuki, N. (2015) Cdc42 Mediates Bmp-Induced Sprouting Angiogenesis through Fmnl3-Driven Assembly of Endothelial Filopodia in Zebrafish. Developmental Cell. 32:109-22
- Zhang, P., He, Q., Chen, D., Liu, W., Wang, L., Zhang, C., Ma, D., Li, W., Liu, B., Liu, F. (2015) G protein-coupled receptor 183 facilitates endothelial-to-hematopoietic transition via Notch1 inhibition. Cell Research. 25:1093-107
- Xiao, A., Wang, Z., Hu, Y., Wu, Y., Luo, Z., Yang, Z., Zu, Y., Li, W., Huang, P., Tong, X., Zhu, Z., Lin, S., and Zhang, B. (2013) Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish. Nucleic acids research. 41(14):e141
- Gomez, G.A., Veldman, M.B., Zhao, Y., Burgess, S., and Lin, S. (2009) Discovery and characterization of novel vascular and hematopoietic genes downstream of etsrp in zebrafish. PLoS One. 4(3):e4994
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