Gene
diaph2
- ID
- ZDB-GENE-090115-1
- Name
- diaphanous-related formin 2
- Symbol
- diaph2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to have Rho GTPase binding activity and actin binding activity. Involved in several processes, including actin filament polymerization; establishment of mitotic spindle localization; and gastrulation. Human ortholog(s) of this gene implicated in premature ovarian failure. Is expressed in head. Orthologous to human DIAPH2 (diaphanous related formin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1025 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary ovarian insufficiency 2A | Alliance | ?Premature ovarian failure 2A | 300511 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR010472 | Formin, FH3 domain |
| Domain | IPR010473 | Formin, GTPase-binding domain |
| Domain | IPR014767 | Diaphanous autoregulatory (DAD) domain |
| Domain | IPR014768 | Rho GTPase-binding/formin homology 3 (GBD/FH3) domain |
| Domain | IPR015425 | Formin, FH2 domain |
| Homologous_superfamily | IPR011989 | Armadillo-like helical |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Homologous_superfamily | IPR042201 | Formin, FH2 domain superfamily |
| Homologous_superfamily | IPR044933 | Diaphanous, GTPase-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Armadillo-like helical | Armadillo-type fold | Diaphanous autoregulatory (DAD) domain | Diaphanous, GTPase-binding domain superfamily | Formin, FH2 domain | Formin, FH2 domain superfamily | Formin, FH3 domain | Formin, GTPase-binding domain | Rho GTPase-binding/formin homology 3 (GBD/FH3) domain |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9QL38
|
1118 | |||||||||
|
UniProtKB:A0A8M9QGW2
|
1145 | |||||||||
|
UniProtKB:A0A8M9QPK7
|
1135 | |||||||||
|
UniProtKB:A0A8M9PZW8
|
1166 | |||||||||
|
UniProtKB:A0A8M9QBN3
|
1155 | |||||||||
|
UniProtKB:A0A8M9PNG4
|
205 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
diaph2-202
(1)
|
Havana | 7546 nt |
Interactions and Pathways
No data available
Plasmids
No data available