Gene
crhr1
- ID
- ZDB-GENE-081231-1
- Name
- corticotropin releasing hormone receptor 1
- Symbol
- crhr1 Nomenclature History
- Previous Names
-
- crfr1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled receptor activity; corticotropin-releasing hormone binding activity; and corticotropin-releasing hormone receptor activity. Acts upstream of or within response to cortisol and response to stress. Predicted to be located in membrane. Predicted to be active in neuron projection and plasma membrane. Is expressed in several structures, including brain; gill; gonad; heart; and liver. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and obesity. Orthologous to human CRHR1 (corticotropin releasing hormone receptor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Faught et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ca403 | Allele with one deletion | Exon 4 | Unknown | CRISPR | |
| la015120Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la015122Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028873Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa2110 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa11535 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19989 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa26049 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-crhr1 | (2) | |
| TALEN1-crhr1 | Bedell et al., 2012 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017983 | GPCR, family 2, secretin-like, conserved site |
| Domain | IPR001879 | GPCR, family 2, extracellular hormone receptor domain |
| Domain | IPR017981 | GPCR, family 2-like, 7TM |
| Family | IPR000832 | GPCR, family 2, secretin-like |
| Family | IPR003051 | GPCR, family 2, corticotropin releasing factor receptor |
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Domain Details Per Protein
| Protein | Length | GPCR, family 2, corticotropin releasing factor receptor | GPCR, family 2, corticotropin releasing factor receptor, type 1 | GPCR, family 2, extracellular hormone receptor domain | GPCR family 2, extracellular hormone receptor domain superfamily | GPCR, family 2-like, 7TM | GPCR, family 2, secretin-like | GPCR, family 2, secretin-like, conserved site | G-protein coupled receptor 2 |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:X1WHD4
|
430 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-221H1 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-35A22 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-202K24 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-225I9 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_691254 (1) | 15091 nt | ||
| Genomic | GenBank:BX547992 (2) | 181320 nt | ||
| Polypeptide | UniProtKB:X1WHD4 (1) | 430 aa |
- Bao, J., Su, B., Chen, Z., Sun, Z., Peng, J., Zhao, S. (2024) A UTP3-dependent nucleolar translocation pathway facilitates pre-rRNA 5'ETS processing. Nucleic acids research. 52(16):9671-9694
- Faught, E., Vijayan, M.M. (2021) Coordinated action of CRH and cortisol shapes acute stress-induced behavioural response in zebrafish. Neuroendocrinology. 112(1):74-87
- Zhou, H., Chen, A., Lu, W. (2021) Corticotropin-releasing hormone reduces basal estradiol production in zebrafish follicular cells. Molecular and Cellular Endocrinology. 527:111222
- Wang, L., Lin, W., Zha, Q., Guo, H., Zhang, D., Yang, L., Li, L., Li, D., Tang, R. (2020) Persistent Exposure to Environmental Levels of Microcystin-LR Disturbs Cortisol Production via Hypothalamic-Pituitary-Interrenal (HPI) Axis and Subsequently Liver Glucose Metabolism in Adult Male Zebrafish (Danio rerio). toxins. 12(5):
- Wei, P., Zhao, F., Zhang, X., Ru, S. (2020) Long-term exposure of zebrafish to bisphenol S impairs stress function of hypothalamic-pituitary-interrenal axis and causes anxiety-like behavioral responses to novelty. The Science of the total environment. 716:137092
- Vera-Chang, M.N., Moon, T.W., Trudeau, V.L. (2019) Cortisol disruption and transgenerational alterations in the expression of stress-related genes in zebrafish larvae following fluoxetine exposure. Toxicology and applied pharmacology. 382:114742
- Chen, L., Wang, Y., Giesy, J.P., Chen, F., Shi, T., Chen, J., Xie, P. (2018) Microcystin-LR affects the hypothalamic-pituitary-inter-renal (HPI) axis in early life stages (embryos and larvae) of zebrafish. Environmental pollution (Barking, Essex : 1987). 241:540-548
- Williams, T.A., Bergstrome, J.C., Scott, J., Bernier, N.J. (2017) CRF and urocortin 3 protect the heart from hypoxia/reoxygenation-induced apoptosis in zebrafish. American journal of physiology. Regulatory, integrative and comparative physiology. 313(2):R91-R100
- Jeffrey, J.D., Gilmour, K.M. (2016) Programming of the hypothalamic-pituitary-interrenal axis by maternal social status in zebrafish (Danio rerio). The Journal of experimental biology. 219(Pt 11):1734-43
- Kwan, W., Cortes, M., Frost, I., Esain, V., Theodore, L.N., Liu, S.Y., Budrow, N., Goessling, W., North, T.E. (2016) The Central Nervous System Regulates Embryonic HSPC Production via Stress-Responsive Glucocorticoid Receptor Signaling. Cell Stem Cell. 19:370-82
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