Gene
frem2b
- ID
- ZDB-GENE-081119-4
- Name
- FRAS1 related extracellular matrix 2b
- Symbol
- frem2b Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to be involved in cell communication. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in Fraser syndrome 2 and isolated cryptophthalmia. Is expressed in intermediate cell mass of mesoderm; median fin fold; and pronephric duct. Orthologous to human FREM2 (FRAS1 related extracellular matrix 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Carney et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Carney et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Fraser syndrome 2 | Alliance | Fraser syndrome 2 | 617666 |
| isolated cryptophthalmia | Alliance | Cryptophthalmos, unilateral or bilateral, isolated | 123570 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002126 | Cadherin-like |
| Domain | IPR003644 | Na-Ca exchanger/integrin-beta4 |
| Domain | IPR045658 | FRAS1-related extracellular matrix protein, N-terminal domain |
| Family | IPR051561 | FRAS1-related extracellular matrix |
| Homologous_superfamily | IPR038081 | CalX-like domain superfamily |
| Repeat | IPR039005 | CSPG repeat |
Domain Details Per Protein
| Protein | Length | Cadherin-like | CalX-like domain superfamily | CSPG repeat | FRAS1-related extracellular matrix | FRAS1-related extracellular matrix protein, N-terminal domain | Na-Ca exchanger/integrin-beta4 |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IH07
|
3112 | ||||||
|
UniProtKB:B6IDE7
|
3116 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| antisense |
ottdart00000051048
(1)
|
Ensembl | 625 nt | ||
| mRNA |
frem2b-201
(1)
|
Ensembl | 9,512 nt | ||
| mRNA |
frem2b-202
(1)
|
Ensembl | 9,725 nt |
Interactions and Pathways
No data available
Plasmids
No data available