Gene
mertka
- ID
- ZDB-GENE-081107-1
- Name
- c-mer proto-oncogene tyrosine kinase a
- Symbol
- mertka Nomenclature History
- Previous Names
-
- mertk (1)
- si:ch1073-268l12.2
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in several processes, including cell migration; cell surface receptor protein tyrosine kinase signaling pathway; and phagocytosis. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in eye. Human ortholog(s) of this gene implicated in retinitis pigmentosa 38. Orthologous to human MERTK (MER proto-oncogene, tyrosine kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| cq49 | Allele with multiple variants | Unknown | Unknown | CRISPR | |
| ihb539 | Allele with one delins | Unknown | Unknown | CRISPR | |
| ihb540 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| la018687Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la027464Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa561 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa15250 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa18550 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa22378 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa28202 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| retinitis pigmentosa 38 | Alliance | Retinitis pigmentosa 38 | 613862 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR003598 | Immunoglobulin subtype 2 |
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Domain Details Per Protein
| Protein | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QWE3
|
952 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mertka-201
(1)
|
Ensembl | 5,697 nt | ||
| mRNA |
mertka-202
(1)
|
Ensembl | 569 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(coro1a:mertka) |
|
| 1 | Zhao et al., 2017 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-268L12 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_002664231 (1) | |||
| Genomic | GenBank:CABZ01057035 (1) | 43001 nt | ||
| Polypeptide | UniProtKB:F1QWE3 (1) | 952 aa |
- Djannatian, M., Radha, S., Weikert, U., Safaiyan, S., Wrede, C., Deichsel, C., Kislinger, G., Rhomberg, A., Ruhwedel, T., Campbell, D.S., van Ham, T., Schmid, B., Hegermann, J., Möbius, W., Schifferer, M., Simons, M. (2023) Myelination generates aberrant ultrastructure that is resolved by microglia. The Journal of cell biology. 222(3):
- Keatinge, M., Tsarouchas, T.M., Munir, T., Porter, N.J., Larraz, J., Gianni, D., Tsai, H.H., Becker, C.G., Lyons, D.A., Becker, T. (2021) CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury. PLoS Genetics. 17:e1009515
- Zou, Q., Gang, K., Yang, Q., Liu, X., Tang, X., Lu, H., He, J., Luo, L. (2018) The CCCH-type zinc finger transcription factor Zc3h8 represses NF-κB-mediated inflammation in digestive organs in zebrafish. The Journal of biological chemistry. 293(31):11971-11983
- Chen, X., Sheng, X., Zhuang, W., Sun, X., Liu, G., Shi, X., Huang, G., Mei, Y., Li, Y., Pan, X., Liu, Y., Li, Z., Zhao, Q., Yan, B., Zhao, C. (2017) GUCA1A mutation causes maculopathy in a five-generation family with a wide spectrum of severity. Genetics in medicine : official journal of the American College of Medical Genetics. 19(8):945-954
- Yu, S., Li, C., Biswas, L., Hu, X., Liu, F., Reilly, J., Liu, X., Liu, Y., Huang, Y., Lu, Z., Han, S., Wang, L., Liu, J.Y., Jiang, T., Shu, X., Wong, F., Tang, Z., Liu, M. (2017) CERKL gene knockout disturbs photoreceptor outer segment phagocytosis and causes rod-cone dystrophy in zebrafish. Human molecular genetics. 26(12):2335-2345
- Zhao, F., Shi, Y., Huang, Y., Zhan, Y., Zhou, L., Li, Y., Wan, Y., Li, H., Huang, H., Ruan, H., Luo, L., Li, L. (2017) Irf8 regulates the progression of myeloproliferative neoplasm (MPN)-like syndrome via Mertk signaling in zebrafish. Leukemia. 32(1):149-158
- Jiang, C., Qin, B., Liu, G., Sun, X., Shi, H., Ding, S., Liu, Y., Zhu, M., Chen, X., Zhao, C. (2016) MicroRNA-184 promotes differentiation of the retinal pigment epithelium by targeting the AKT2/mTOR signaling pathway. Oncotarget. 7(32):52340-52353
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Maugars, G., Dufour, S. (2015) Demonstration of the Coexistence of Duplicated LH Receptors in Teleosts, and Their Origin in Ancestral Actinopterygians. PLoS One. 10:e0135184
- Russell, M.W., Raeker, M.O., Geisler, S.B., Thomas, P.E., Simmons, T.A., Bernat, J.A., Thorsson, T., Innis, J.W. (2014) Functional analysis of candidate genes in 2q13 deletion syndrome implicates FBLN7 and TMEM87B deficiency in congenital heart defects and FBLN7 in craniofacial malformations. Human molecular genetics. 23(16):4272-84
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