Gene
ccdc141
- ID
- ZDB-GENE-081104-472
- Name
- coiled-coil domain containing 141
- Symbol
- ccdc141 Nomenclature History
- Previous Names
-
- si:dkeyp-122a11.1
- si:dkeyp-67d2.4
- si:dkeyp-67d2.5
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Acts upstream of or within regulation of amacrine cell differentiation and swimming. Orthologous to human CCDC141 (coiled-coil domain containing 141).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Jiang et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa947 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11814 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15829 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa18522 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34749 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa41541 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zf3535 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| zf3536 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| zf3537 | Allele with one insertion | Exon 2 | Unknown | not specified |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | IgLON domain-containing protein | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1QHJ9 | InterPro | 1738 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ccdc141-201
(1)
|
Ensembl | 5,950 nt | ||
| mRNA |
ccdc141-202
(1)
|
Ensembl | 808 nt | ||
| mRNA |
ccdc141-203
(1)
|
Ensembl | 596 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-67D2 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-122A11 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068223673 (1) | 5374 nt | ||
| Genomic | GenBank:BX640499 (2) | 184606 nt | ||
| Polypeptide | UniProtKB:A0A8M1QHJ9 (1) | 1738 aa |
- Wang, P., Shi, W., Liu, S., Shi, Y., Jiang, X., Li, F., Chen, S., Sun, K., Xu, R. (2024) ccdc141 is required for left-right axis development by regulating cilia formation in the Kupffer's vesicle of zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 51(9):934-946
- Jiang, Y.J., Fann, C.S., Fuh, J.L., Chung, M.Y., Huang, H.Y., Chu, K.C., Wang, Y.F., Hsu, C.L., Kao, L.S., Chen, S.P., Wang, S.J. (2022) Genome-wide analysis identified novel susceptible genes of restless legs syndrome in migraineurs. The journal of headache and pain. 23:39
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Riera, M., Burguera, D., Garcia-Fernàndez, J., and Gonzàlez-Duarte, R. (2013) CERKL Knockdown Causes Retinal Degeneration in Zebrafish. PLoS One. 8(5):e64048
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