ZFIN is now using GRCz12tu for Genomic Data
Gene
rnf220b
- ID
- ZDB-GENE-081104-195
- Name
- ring finger protein 220b
- Symbol
- rnf220b Nomenclature History
- Previous Names
-
- si:ch211-241d21.7
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 23. Orthologous to human RNF220 (ring finger protein 220).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypomyelinating leukodystrophy 23 | Alliance | Leukodystrophy, hypomyelinating, 23, with ataxia, deafness, liver dysfunction, and dilated cardiomyopathy | 619688 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001841 | Zinc finger, RING-type |
| Domain | IPR031824 | E3 ubiquitin-protein ligase RNF220, middle domain |
| Domain | IPR040178 | E3 ubiquitin-protein ligase RNF220, RING finger |
| Family | IPR052443 | E3 ubiquitin-protein ligase RNF220-like |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
Domain Details Per Protein
| Protein | Additional Resources | Length | E3 ubiquitin-protein ligase RNF220-like | E3 ubiquitin-protein ligase RNF220, middle domain | E3 ubiquitin-protein ligase RNF220, RING finger | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8N7TAR9 | InterPro | 588 | |||||
| UniProtKB:A0AC58G975 | InterPro | 656 | |||||
| UniProtKB:A0AC58G980 | InterPro | 684 | |||||
| UniProtKB:A0AC58G982 | InterPro | 656 | |||||
| UniProtKB:A0AC58G985 | InterPro | 649 | |||||
| UniProtKB:A0AC58G990 | InterPro | 621 | |||||
| UniProtKB:A0AC58G991 | InterPro | 621 | |||||
| UniProtKB:A0AC58G998 | InterPro | 656 | |||||
| UniProtKB:A0A8M6Z2A0 | InterPro | 553 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rnf220-203
(1)
|
Ensembl | 1,903 nt | ||
| mRNA |
rnf220b-201
(1)
|
Ensembl | 1,108 nt | ||
| mRNA |
rnf220b-202
(1)
|
Ensembl | 3,450 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers