ZFIN is now using GRCz12tu for Genomic Data
Gene
npm1b
- ID
- ZDB-GENE-080723-7
- Name
- nucleophosmin 1b
- Symbol
- npm1b Nomenclature History
- Previous Names
-
- npm4
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable RNA binding activity; chromatin binding activity; and histone binding activity. Acts upstream of or within hemopoiesis and regulation of apoptotic process. Predicted to be part of ribonucleoprotein complex. Predicted to be active in centrosome; cytoplasm; and nuclear lumen. Is expressed in several structures, including eye; fin bud; hematopoietic cell; hematopoietic stem cell; and somite. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human NPM1 (nucleophosmin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Bolli et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Bolli et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute myeloid leukemia | Alliance | Leukemia, acute myeloid, somatic | 601626 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Nucleophosmin, C-terminal | Nucleoplasmin core domain | Nucleoplasmin core domain superfamily | Nucleoplasmin family |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1NVF2 | InterPro | 298 | ||||
| UniProtKB:A0A8M2BKD3 | InterPro | 316 | ||||
| UniProtKB:Q566X7 | InterPro | 307 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers