Gene

nsmfb

ID

ZDB-GENE-080603-4

Name

NMDA receptor synaptonuclear signaling and neuronal migration factor b

Symbol

nsmfb Nomenclature History

Previous Names

nelf
nelfb
si:ch73-239f21.1

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Involved in positive regulation of axon extension and positive regulation of neuron migration. Predicted to be located in several cellular components, including dendrite; nucleus; and postsynaptic density. Predicted to be active in cytoplasm and nucleus. Is expressed in brain and olfactory epithelium. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 7 with or without anosmia and hypogonadotropic hypogonadism 9 with or without anosmia. Orthologous to human NSMF (NMDA receptor synaptonuclear signaling and neuronal migration factor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from Palevitch et al., 2009

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa33616	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)
sa38476	Allele with one point mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa40442	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)

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Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Citations
MO1-nsmfb	N/A	Palevitch et al., 2009
MO2-nsmfb	N/A	Palevitch et al., 2009

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Human Disease

Associated With nsmfb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hypogonadotropic hypogonadism 9 with or without anosmia	Alliance	Hypogonadotropic hypogonadism 9 with or without anosmia	614838

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Associated With nsmfb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR033374	NMDA receptor synaptonuclear signalling and neuronal migration factor

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Domain Details Per Protein

Protein	Length	NMDA receptor synaptonuclear signalling and neuronal migration factor
UniProtKB:A0A8M9Q3Q1 InterPro	579
UniProtKB:A0A0R4INI9 InterPro	568
UniProtKB:A0A8M9PY12 InterPro	593
UniProtKB:B8PYG1 InterPro	570
UniProtKB:A0A8M9Q8Z5 InterPro	560

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Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 5

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	nsmfb-201 (1) Ensembl	Ensembl	934 nt	Select Tool ZFIN BLAST
mRNA	nsmfb-202 (1) Ensembl	Ensembl	6,760 nt	Select Tool ZFIN BLAST
mRNA	nsmfb-203 (1) Ensembl	Ensembl	1,206 nt	Select Tool ZFIN BLAST
mRNA	nsmfb-204 (1) Ensembl	Ensembl	1,713 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	CH73-239F21	CT025870
Contained in	BAC	DKEYP-86B9	BX323557

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001143901 (1)	2780 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX323557 (1)	223754 nt	Select Tool MegaBLAST
Polypeptide	UniProtKB:A0A8M9PY12 (1)	593 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	NSMF	9	Ensembl:ENSG00000165802 Gene:26012 OMIM:608137 HGNC:29843	Amino acid sequence comparison (1)

Citations

Include unpublished citations

Palevitch, O., Abraham, E., Borodovsky, N., Levkowitz, G., Zohar, Y., and Gothilf, Y. (2009) Nasal embryonic LHRH factor plays a role in the developmental migration and projection of gonadotropin-releasing hormone 3 neurons in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(1):66-75

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