Gene
vps39
- ID
- ZDB-GENE-080530-2
- Name
- VPS39 subunit of HOPS complex
- Symbol
- vps39 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Involved in developmental pigmentation; eye development; and vesicle-mediated transport. Is expressed in brain; digestive system; head; and integument. Orthologous to human VPS39 (VPS39 subunit of HOPS complex).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 2 figures from Schonthaler et al., 2008
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 8 figures from Schonthaler et al., 2008
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa9171 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa9687 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa14550 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa18429 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
t20290 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 5 of 5
Show
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR001180 | Citron homology (CNH) domain |
Domain | IPR019452 | Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 1 |
Domain | IPR019453 | Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 2 |
Family | IPR032914 | Vam6/VPS39/TRAP1 family |
Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
1 - 5 of 6 Show all
Domain Details Per Protein
Protein | Length | Citron homology (CNH) domain | Clathrin, heavy chain/VPS, 7-fold repeat | Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 1 | Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 2 | Vam6/VPS39/TRAP1 family | WD40-repeat-containing domain superfamily |
---|---|---|---|---|---|---|---|
UniProtKB:B0EXK3
|
875 | ||||||
UniProtKB:A0A8M2B5G7
|
874 | ||||||
UniProtKB:A0A8N1YZ39
|
875 |
1 - 3 of 3
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-240M14 | ZFIN Curated Data | |
Contained in | Fosmid | CH1073-372I3 | ZFIN Curated Data |
1 - 2 of 2
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001113540 (1) | 5923 nt | ||
Genomic | GenBank:CU655820 (2) | 96560 nt | ||
Polypeptide | UniProtKB:A0A8N1YZ39 (1) | 875 aa |
- Luo, H., Zhang, Y., Deng, Y., Li, L., Sheng, Z., Yu, Y., Lin, Y., Chen, X., Feng, P. (2021) Nxhl Controls Angiogenesis by Targeting VE-PTP Through Interaction With Nucleolin. Frontiers in cell and developmental biology. 9:728821
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Schonthaler, H.B., Fleisch, V.C., Biehlmaier, O., Makhankov, Y., Rinner, O., Bahadori, R., Geisler, R., Schwarz, H., Neuhauss, S.C., and Dahm, R. (2008) The zebrafish mutant lbk/vam6 resembles human multi-systemic disorders caused by aberrant trafficking of endosomal vesicles. Development (Cambridge, England). 135(2):387-399
1 - 4 of 4
Show