Gene
slc18a2
- ID
- ZDB-GENE-080514-1
- Name
- solute carrier family 18 member 2
- Symbol
- slc18a2 Nomenclature History
- Previous Names
-
- vmat2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to have serotonin:sodium symporter activity. Involved in swimming behavior. Predicted to localize to synaptic vesicle membrane and terminal bouton. Used to study anxiety disorder. Human ortholog(s) of this gene implicated in Parkinson's disease and type 1 diabetes mellitus. Is expressed in brain and neurons. Orthologous to human SLC18A2 (solute carrier family 18 member A2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
infantile parkinsonism-dystonia 2 | Alliance | Parkinsonism-dystonia, infantile, 2 | 618049 |
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
anxiety disorder | slc18a2sus100/+ | standard conditions | Wang et al., 2016 |
anxiety disorder | slc18a2sus101/+ | standard conditions | Wang et al., 2016 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Major facilitator superfamily | Major facilitator superfamily domain | Major Facilitator Superfamily Vesicular Transporter | MFS transporter superfamily | Multidrug resistance protein |
---|---|---|---|---|---|---|
UniProtKB:Q5CZP4
|
562 | |||||
UniProtKB:A0A8M1P3E9
|
515 |
Type | Name | Annotation Method | Length (nt) | Analysis |
---|---|---|---|---|
mRNA |
slc18a2-201
(1)
|
Havana | 1762 nt |
Interactions and Pathways
No data available
Plasmids
No data available