Gene

ep300b

ID

ZDB-GENE-080403-15

Name

E1A binding protein p300 b

Symbol

ep300b Nomenclature History

Previous Names

EP300a (1)
P300-B (1)
fj84f01
gb:dq017642
wu:fj84f01

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have histone acetyltransferase activity; transcription coactivator activity; and zinc ion binding activity. Involved in embryonic cranial skeleton morphogenesis; heart looping; and pectoral fin development. Predicted to localize to histone acetyltransferase complex. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; colorectal cancer; and congestive heart failure. Is expressed in blastoderm; blastomere; brain; intestinal bulb; and ventricular zone. Orthologous to human EP300 (E1A binding protein p300).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

dq017642 (8 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ep300b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
colorectal cancer	Alliance	Colorectal cancer, somatic	114500
Rubinstein-Taybi syndrome	Alliance	Rubinstein-Taybi syndrome 2	613684
		Menke-Hennekam syndrome 2	618333

Associated With ep300b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018359	Bromodomain, conserved site
Domain	IPR000197	Zinc finger, TAZ-type
Domain	IPR000433	Zinc finger, ZZ-type
Domain	IPR001487	Bromodomain
Domain	IPR003101	Coactivator CBP, KIX domain
Domain	IPR010303	CREB-binding protein/p300, atypical RING domain
Domain	IPR014744	Nuclear receptor coactivator, CREB-bp-like, interlocking
Domain	IPR031162	CBP/p300-type histone acetyltransferase domain
Family	IPR013178	Histone acetyltransferase Rtt109/CBP
Homologous_superfamily	IPR009110	Nuclear receptor coactivator, interlocking
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR035898	TAZ domain superfamily
Homologous_superfamily	IPR036427	Bromodomain-like superfamily
Homologous_superfamily	IPR036529	Coactivator CBP, KIX domain superfamily
Homologous_superfamily	IPR038547	CBP/p300, atypical RING domain superfamily
Homologous_superfamily	IPR043145	Zinc finger, ZZ-type superfamily

Domain Details Per Protein

Protein	Length	Bromodomain	Bromodomain, conserved site	Bromodomain-like superfamily	CBP/p300, atypical RING domain superfamily	CBP/p300-type histone acetyltransferase domain	Coactivator CBP, KIX domain	Coactivator CBP, KIX domain superfamily	CREB-binding protein/p300, atypical RING domain	Histone acetyltransferase Rtt109/CBP	Nuclear receptor coactivator, CREB-bp-like, interlocking	Nuclear receptor coactivator, interlocking	TAZ domain superfamily	Zinc finger, RING/FYVE/PHD-type	Zinc finger, TAZ-type	Zinc finger, ZZ-type	Zinc finger, ZZ-type superfamily
UniProtKB:A0A8M3AXZ0 InterPro	2617
UniProtKB:A0A8M3B890 InterPro	2636
UniProtKB:A0A8M3B0W3 InterPro	2645
UniProtKB:A0A8M3AQU7 InterPro	2635
UniProtKB:A0A8M3AQI0 InterPro	2639
UniProtKB:A0A8M3AXY5 InterPro	2645
UniProtKB:A0A8M3B0X0 InterPro	2625
UniProtKB:A0A8M3AQU5 InterPro	2646

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ep300b-202 (1) Ensembl	Havana	10791 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations