Gene
tiam1a
- ID
- ZDB-GENE-080325-1
- Name
- TIAM Rac1 associated GEF 1a
- Symbol
- tiam1a Nomenclature History
- Previous Names
-
- tiam1
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have Rac guanyl-nucleotide exchange factor activity. Predicted to be involved in activation of GTPase activity; positive regulation of axonogenesis; and small GTPase mediated signal transduction. Predicted to localize to cytosol; plasma membrane; and synapse. Orthologous to human TIAM1 (TIAM Rac1 associated GEF 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| neurodevelopmental disorder with language delay and seizures | Alliance | Neurodevelopmental disorder with language delay and seizures | 619908 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001331 | Guanine-nucleotide dissociation stimulator, CDC24, conserved site |
| Domain | IPR000219 | Dbl homology (DH) domain |
| Domain | IPR001478 | PDZ domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR003116 | Raf-like Ras-binding |
| Domain | IPR040655 | TIAM1, CC-Ex domain |
| Family | IPR043537 | Tiam1/Tiam2/Protein still life |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR035899 | Dbl homology (DH) domain superfamily |
| Homologous_superfamily | IPR036034 | PDZ superfamily |
Domain Details Per Protein
| Protein | Length | Dbl homology (DH) domain | Dbl homology (DH) domain superfamily | Guanine-nucleotide dissociation stimulator, CDC24, conserved site | PDZ domain | PDZ superfamily | PH-like domain superfamily | Pleckstrin homology domain | Raf-like Ras-binding | TIAM1, CC-Ex domain | Tiam1/Tiam2/Protein still life |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E7FBR4
|
1621 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tiam1a-201
(1)
|
Ensembl | 7,107 nt | ||
| mRNA |
tiam1a-202
(1)
|
Ensembl | 800 nt | ||
| mRNA |
tiam1a-204
(1)
|
Ensembl | 6,328 nt | ||
| ncRNA |
tiam1a-003
(1)
|
Ensembl | 727 nt |
Interactions and Pathways
No data available
Plasmids
No data available