Gene
ccn4b
- ID
- ZDB-GENE-080220-16
- Name
- cellular communication network factor 4b
- Symbol
- ccn4b Nomenclature History
- Previous Names
-
- wisp1b
- zgc:172276
- zWISP1-c16 (1)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable heparin binding activity and integrin binding activity. Predicted to be involved in cell adhesion; positive regulation of cell differentiation; and signal transduction. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix and extracellular space. Is expressed in thyroid follicle. Orthologous to human CCN4 (cellular communication network factor 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ccn4b | Zebrafish Nomenclature Committee |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CCN, TSP1 domain | Cellular Communication Network Factor | Cystine knot, C-terminal | Glycoprotein hormone subunit beta | Growth factor receptor cysteine-rich domain superfamily | IGFBP-related, CNN | Insulin-like growth factor-binding protein, IGFBP | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily | VWFC domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A8WG98 | InterPro | 356 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
wisp1b-201
(1)
|
Ensembl | 1,600 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-97I18 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:172276 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198268 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198270 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001113628 (1) | 1654 nt | ||
| Genomic | GenBank:CR855311 (1) | 161379 nt | ||
| Polypeptide | UniProtKB:A8WG98 (1) | 356 aa |
- Khayrullin, A., Smith, L., Mistry, D., Dukes, A., Pan, Y.A., Hamrick, M.W. (2016) Chronic alcohol exposure induces muscle atrophy (myopathy) in zebrafish and alters the expression of microRNAs targeting the Notch pathway in skeletal muscle. Biochemical and Biophysical Research Communications. 479(3):590-595
- Zhang, H., Wang, X., Lv, K., Gao, S., Wang, G., Fan, C., Zhang, X.A., Yan, J. (2015) Time Point-based Integrative Analyses of Deep-transcriptome Identify Four Signal Pathways in Blastemal Regeneration of Zebrafish Lower Jaw. Stem cells (Dayton, Ohio). 33(3):806-18
- Fernando, C.A., Conrad, P.A., Bartels, C.F., Marques, T., To, M., Balow, S.A., Nakamura, Y., and Warman, M.L. (2010) Temporal and spatial expression of CCN genes in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(6):1755-1767
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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