Gene
prkd1
- ID
- ZDB-GENE-080131-1
- Name
- protein kinase D1
- Symbol
- prkd1 Nomenclature History
- Previous Names
-
- PKD1 (1)
- si:dkeyp-47g2.1
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity; calcium-dependent protein kinase C activity; and metal ion binding activity. Involved in regulation of angiogenesis and regulation of lymphangiogenesis. Predicted to localize to cytoplasm. Orthologous to human PRKD1 (protein kinase D1).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 1 figure from Hollenbach et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Hollenbach et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Congenital heart defects and ectodermal dysplasia | 617364 |
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Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
Binding_site | IPR017441 | Protein kinase, ATP binding site |
Domain | IPR000719 | Protein kinase domain |
Domain | IPR001849 | Pleckstrin homology domain |
Domain | IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
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Domain Details Per Protein
Protein | Length | C1-like domain superfamily | Diacylglycerol/phorbol-ester binding | PH-like domain superfamily | Pleckstrin homology domain | Protein kinase, ATP binding site | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Protein kinase C mu-related | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M9PPI9
|
878 | ||||||||||
UniProtKB:X1WHC7
|
886 |
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Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab1-prkd1 | polyclonal | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
2 |
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Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEYP-47G2 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_005158816 (1) | 3692 nt | ||
Genomic | GenBank:CR925802 (1) | 163863 nt | ||
Polypeptide | UniProtKB:X1WHC7 (1) | 886 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Hollenbach, M., Stoll, S.J., Jörgens, K., Seufferlein, T., and Kroll, J. (2013) Different Regulation of Physiological and Tumor Angiogenesis in Zebrafish by Protein Kinase D1 (PKD1). PLoS One. 8(7):e68033
- Chen, J.Y., Wei, C.C., Chiou, M.J., Su, H.Y., and Kuo, C.M. (2007) Cloning and Expression Analysis of a Protein Kinase C Gene, PKCmu, and Its Regulation of the Promoter Region in Zebrafish. DNA and cell biology. 26(6):415-424
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