Gene

vwa8

ID

ZDB-GENE-070912-407

Name

von Willebrand factor A domain containing 8

Symbol

vwa8 Nomenclature History

Previous Names

si:dkey-18l1.1

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to enable ATP hydrolysis activity. Acts upstream of or within notochord development. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in retinitis pigmentosa 97. Orthologous to human VWA8 (von Willebrand factor A domain containing 8).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from Umair et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With vwa8 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
retinitis pigmentosa 97	Alliance	?Retinitis pigmentosa 97	620422

Associated With vwa8 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002035	von Willebrand factor, type A
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR011704	ATPase, dynein-related, AAA domain
Family	IPR039891	von Willebrand factor A domain-containing protein 8
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036465	von Willebrand factor A-like domain superfamily