adamtsl4

ID

ZDB-GENE-070815-2

Name

ADAMTS-like 4

Symbol

adamtsl4 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in autosomal recessive isolated ectopia lentis 2 and ectopia lentis with ectopia of pupil. Orthologous to human ADAMTSL4 (ADAMTS like 4).

Genome Resources

Alliance (1)
Gene:100333903 (1)

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Tevar et al., 2025

Cross-Species Comparison

Alliance

High Throughput Data

Expression Atlas

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 11 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With adamtsl4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive isolated ectopia lentis 2	Alliance	Ectopia lentis, isolated, autosomal recessive	225100
ectopia lentis with ectopia of pupil	Alliance	Ectopia lentis et pupillae	225200

Associated With adamtsl4 Via Experimental Models

Human Disease	Fish	Conditions	Citations
craniosynostosis	adamtsl4^ucl6/ucl6 (AB)	standard conditions	Tevar et al., 2025
ectopia lentis with ectopia of pupil	adamtsl4^ucl6/ucl6 (AB)	standard conditions	Tevar et al., 2025

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR010294	ADAMTS/ADAMTS-like, Spacer 1
Domain	IPR010909	PLAC
Domain	IPR045371	ADAMTS/ADAMTS-like, cysteine-rich domain 3
Family	IPR050439	ADAMTS and ADAMTS-like
Homologous_superfamily	IPR036383	Thrombospondin type-1 (TSP1) repeat superfamily
Repeat	IPR000884	Thrombospondin type-1 (TSP1) repeat