Gene
casp8l1
- ID
- ZDB-GENE-070608-1
- Name
- caspase 8, apoptosis-related cysteine peptidase, like 1
- Symbol
- casp8l1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have cysteine-type endopeptidase activity involved in apoptotic signaling pathway. Predicted to be involved in activation of cysteine-type endopeptidase activity involved in apoptotic process and apoptotic process. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 2B; breast cancer; hepatocellular carcinoma; pancreatic cancer; and primary immunodeficiency disease. Orthologous to human CASP8 (caspase 8).
- Genome Resources
-
- Alliance (1)
- Gene:100049706 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Spead et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR033139 | Peptidase family C14A, cysteine active site |
Domain | IPR001309 | Peptidase C14, p20 domain |
Domain | IPR002138 | Peptidase C14, caspase non-catalytic subunit p10 |
Domain | IPR011600 | Peptidase C14, caspase domain |
Domain | IPR015917 | Peptidase C14A, caspase catalytic domain |
Family | IPR051290 | CASP8 and FADD-like apoptosis regulator |
Homologous_superfamily | IPR029030 | Caspase-like domain superfamily |
Domain Details Per Protein
Protein | Length | CASP8 and FADD-like apoptosis regulator | Caspase-like domain superfamily | Peptidase C14A, caspase catalytic domain | Peptidase C14, caspase domain | Peptidase C14, caspase non-catalytic subunit p10 | Peptidase C14, p20 domain | Peptidase family C14A, cysteine active site |
---|---|---|---|---|---|---|---|---|
UniProtKB:Q0PKX1
|
330 | |||||||
UniProtKB:A0A2U9DQL0
|
330 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance