Gene
ngfrb
- ID
- ZDB-GENE-070606-2
- Name
- nerve growth factor receptor b
- Symbol
- ngfrb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to have coreceptor activity; death receptor activity; and nerve growth factor binding activity. Involved in posterior lateral line neuromast deposition. Predicted to localize to cell surface and plasma membrane. Is expressed in cranial ganglion; posterior lateral line primordium; and trigeminal ganglion. Human ortholog(s) of this gene implicated in Alzheimer's disease and mental depression. Orthologous to human NGFR (nerve growth factor receptor).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000488 | Death domain |
Domain | IPR001368 | TNFR/NGFR cysteine-rich region |
Domain | IPR034046 | Tumor necrosis factor receptor 16, N-terminal |
Domain | IPR041448 | Tumor necrosis factor receptor member 16, transmembrane domain |
Family | IPR022325 | Tumour necrosis factor receptor 16 |
Family | IPR052302 | Neurotrophin receptor-related death domain-containing protein |
Homologous_superfamily | IPR011029 | Death-like domain superfamily |
Domain Details Per Protein
Protein | Length | Death domain | Death-like domain superfamily | Neurotrophin receptor-related death domain-containing protein | TNFR/NGFR cysteine-rich region | Tumor necrosis factor receptor 16, N-terminal | Tumor necrosis factor receptor member 16, transmembrane domain | Tumour necrosis factor receptor 16 |
---|---|---|---|---|---|---|---|---|
UniProtKB:E2DGP8
|
431 |
Interactions and Pathways
No data available
Plasmids
No data available