Gene
rasgrp3
- ID
- ZDB-GENE-070424-82
- Name
- RAS guanyl releasing protein 3 (calcium and DAG-regulated)
- Symbol
- rasgrp3 Nomenclature History
- Previous Names
-
- zgc:162151
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to act upstream of or within small GTPase-mediated signal transduction. Predicted to be active in plasma membrane. Is expressed in blood island; central nervous system; and trunk vasculature. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human RASGRP3 (RAS guanyl releasing protein 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Gomez et al., 2009
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR018247 | EF-Hand 1, calcium-binding site |
| Domain | IPR000651 | Ras-like guanine nucleotide exchange factor, N-terminal |
| Domain | IPR001895 | Ras guanine-nucleotide exchange factors catalytic domain |
| Domain | IPR002048 | EF-hand domain |
| Domain | IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| Domain | IPR020454 | Diacylglycerol/phorbol-ester binding |
| Family | IPR008937 | Ras-like guanine nucleotide exchange factor |
| Homologous_superfamily | IPR011992 | EF-hand domain pair |
| Homologous_superfamily | IPR023578 | Ras guanine nucleotide exchange factor domain superfamily |
| Homologous_superfamily | IPR036964 | Ras guanine-nucleotide exchange factor, catalytic domain superfamily |
| Homologous_superfamily | IPR046349 | C1-like domain superfamily |
Domain Details Per Protein
| Protein | Length | C1-like domain superfamily | Diacylglycerol/phorbol-ester binding | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Ras guanine-nucleotide exchange factor, catalytic domain superfamily | Ras guanine nucleotide exchange factor domain superfamily | Ras guanine-nucleotide exchange factors catalytic domain | Ras-like guanine nucleotide exchange factor | Ras-like guanine nucleotide exchange factor, N-terminal |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A4QNU6
|
708 | |||||||||||
|
UniProtKB:A0A8M2B4V9
|
708 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rasgrp3-201
(1)
|
Ensembl | 3,394 nt |
Interactions and Pathways
No data available
Plasmids
No data available