Gene

kitlgb

ID

ZDB-GENE-070424-2

Name

kit ligand b

Symbol

kitlgb Nomenclature History

Previous Names

kitlb (1)

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to enable cytokine activity and stem cell factor receptor binding activity. Acts upstream of or within embryonic hemopoiesis and hematopoietic stem cell homeostasis. Predicted to be located in several cellular components, including extracellular region; filopodium; and lamellipodium. Predicted to be active in plasma membrane. Is expressed in several structures, including caudal vein plexus; central nervous system; gonad; kidney; and otic vesicle. Human ortholog(s) of this gene implicated in Waardenburg's syndrome; autosomal dominant nonsyndromic deafness 69; and familial progressive hyperpigmentation with or without hypopigmentation. Orthologous to human KITLG (KIT ligand).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 5 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Mahony et al., 2018
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kitlgb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 69	Alliance	Deafness, autosomal dominant 69, unilateral or asymmetric	616697
familial progressive hyperpigmentation with or without hypopigmentation	Alliance	Hyperpigmentation with or without hypopigmentation	145250
		Waardenburg syndrome, type 2F	619947
		[Skin/hair/eye pigmentation 7, blond/brown hair]	611664

Associated With kitlgb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR003452	Stem cell factor
Homologous_superfamily	IPR009079	Four-helical cytokine-like, core

Domain Details Per Protein

Protein	Length	Four-helical cytokine-like, core	Stem cell factor
UniProtKB:Q56JH5 InterPro	267

Transcripts

Genome Browsers

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	kitlgb-201 (1) Ensembl	Ensembl		1,845 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations