Gene

f7l

ID

ZDB-GENE-070424-102

Name

coagulation factor VII, like

Symbol

f7l Nomenclature History

Previous Names

zgc:163025

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to enable serine-type endopeptidase activity. Predicted to be involved in blood coagulation. Predicted to act upstream of or within proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular space.

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa5652	Allele with one point mutation	Unknown	Premature Stop	ENU
sa15303	Allele with one point mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa32569	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)
sa45061	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)
zko1a	Allele with one delins	Unknown	Unknown	CRISPR	China Zebrafish Resource Center (CZRC) (order this)

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Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Citations
CRISPR1-f7l	zko1a	China Zebrafish Resource Center (CZRC)

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Human Disease

Associated With f7l Human Ortholog

No data available

Associated With f7l Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR018114	Serine proteases, trypsin family, histidine active site
Active_site	IPR033116	Serine proteases, trypsin family, serine active site
Domain	IPR000294	Gamma-carboxyglutamic acid-rich (GLA) domain
Domain	IPR000742	EGF-like domain
Domain	IPR001254	Serine proteases, trypsin domain

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Domain Details Per Protein

Protein	Additional Resources	Length	Coagulation factor-like, Gla domain superfamily	EGF-like calcium-binding domain	EGF-like domain	EGF-type aspartate/asparagine hydroxylation site	Gamma-carboxyglutamic acid-rich (GLA) domain	Gamma-carboxyglutamic acid-rich (GLA) domain superfamily	Peptidase S1A, chymotrypsin family	Peptidase S1A, coagulation factor VII/IX/X/C/Z	Peptidase S1 family, coagulation factors	Peptidase S1, PA clan	Peptidase S1, PA clan, chymotrypsin-like fold	Serine proteases, trypsin domain	Serine proteases, trypsin family, histidine active site	Serine proteases, trypsin family, serine active site
UniProtKB:F1R612	InterPro	431

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Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 1

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	f7 (1 of many)-201 (1) Ensembl	Ensembl		2,870 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	Fosmid	CH1073-411K23	FP067451	ZFIN Curated Data
Contained in	Fosmid	ZFOS-1962A1	FP017167	ZFIN Curated Data
Encodes	cDNA	MGC:163025	BC139693	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001089558 (1)	2862 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:FP017167 (2)	39043 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:F1R612 (1)	431 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance

No data available

Citations

Include unpublished citations

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

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