ide

ID

ZDB-GENE-070410-85

Name

insulin-degrading enzyme

Symbol

ide Nomenclature History

Previous Names

zgc:162603 (1)

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable metalloendopeptidase activity. Acts upstream of or within pancreas regeneration and type B pancreatic cell development. Predicted to be active in cytosol; mitochondrion; and peroxisomal matrix. Is expressed in myotome. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to human IDE (insulin degrading enzyme).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from O'Hare et al., 2016
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ide Human Ortholog

No data available

Associated With ide Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR001431	Peptidase M16, zinc-binding site
Domain	IPR007863	Peptidase M16, C-terminal
Domain	IPR011765	Peptidase M16, N-terminal
Domain	IPR032632	Peptidase M16, middle/third domain
Domain	IPR054734	Coenzyme PQQ synthesis protein F-like, C-terminal lobe, domain 4
Family	IPR050626	Peptidase M16
Homologous_superfamily	IPR011249	Metalloenzyme, LuxS/M16 peptidase-like