syngap1b

ID

ZDB-GENE-100921-2

Name

synaptic Ras GTPase activating protein 1b

Symbol

syngap1b Nomenclature History

Previous Names

syngap1
si:dkey-246f6.1

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable GTPase activator activity. Acts upstream of or within brain morphogenesis and swimming behavior. Is expressed in hindbrain and optic tectum. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 5. Orthologous to human SYNGAP1 (synaptic Ras GTPase activating protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With syngap1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant intellectual developmental disorder 5	Alliance	Intellectual developmental disorder, autosomal dominant 5	612621

Associated With syngap1b Via Experimental Models

Human Disease	Fish	Conditions	Citations
autism spectrum disorder	syngap1b^tup1a/+ (NHGRI-1)	standard conditions	Colón-Rodríguez et al., 2020
autism spectrum disorder	syngap1b^tup1a/tup1a (NHGRI-1)	standard conditions	Colón-Rodríguez et al., 2020

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023152	Ras GTPase-activating protein, conserved site
Domain	IPR000008	C2 domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR001936	Ras GTPase-activating domain
Domain	IPR021887	Disabled homolog 2-interacting protein, C-terminal domain
Family	IPR039360	Ras GTPase-activating protein
Homologous_superfamily	IPR008936	Rho GTPase activation protein
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035892	C2 domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M9NZ00	InterPro	1391
UniProtKB:A0A8M9NZ04	InterPro	1355
UniProtKB:A0A8M9PM32	InterPro	1419
UniProtKB:A0A8M9PM37	InterPro	1380
UniProtKB:A0A8M9PCU4	InterPro	1428
UniProtKB:E7F1U4	InterPro	1507
UniProtKB:A0A8M9P7N6	InterPro	1447
UniProtKB:A0A8M9NYZ5	InterPro	1449
UniProtKB:A0A8M9PJ45	InterPro	1394
UniProtKB:A0A8M9P7P3	InterPro	1341
UniProtKB:A0A8M9PM42	InterPro	1257
UniProtKB:A0A8M9PCV2	InterPro	1297
UniProtKB:A0A8M9P7P0	InterPro	1383
UniProtKB:A0A8M9PJ51	InterPro	1372
UniProtKB:A0AB32T267	InterPro	1315
UniProtKB:A0AB32T268	InterPro	1399
UniProtKB:A0AB32T4G0	InterPro	1505
UniProtKB:A0AB32T4V8	InterPro	1313
UniProtKB:A0AB32T5V2	InterPro	1477
UniProtKB:A0AB32T606	InterPro	1452
UniProtKB:A0AB32T7B5	InterPro	1441
UniProtKB:A0AB32T7T0	InterPro	1249
UniProtKB:A0AB32T933	InterPro	1430
UniProtKB:A0AB32T967	InterPro	1413
UniProtKB:A0AB32T9G1	InterPro	1486
UniProtKB:A0AB32TAU7	InterPro	1438