Gene
drosha
- ID
- ZDB-GENE-070209-23
- Name
- drosha ribonuclease III
- Symbol
- drosha Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable ribonuclease III activity. Acts upstream of or within with a positive effect on primary miRNA processing. Acts upstream of or within angiogenesis. Predicted to be part of microprocessor complex. Predicted to be active in nucleus. Orthologous to human DROSHA (drosha ribonuclease III).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7150667 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Jiang et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la018047Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa191 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13985 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17917 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31863 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35230 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sfc22 | Allele with one deletion | Exon 2 | Frameshift, Premature Stop | CRISPR | |
| sfc23 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sfc25 | Allele with one deletion | Unknown | Unknown | CRISPR |
1 - 9 of 9
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-drosha | (2) | |
| MO1-drosha | N/A | Jiang et al., 2018 |
| MO2-drosha | N/A | Jiang et al., 2018 |
1 - 3 of 3
Show
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000999 | Ribonuclease III domain |
| Domain | IPR014720 | Double-stranded RNA-binding domain |
| Domain | IPR044442 | RNase III, double-stranded RNA binding domain, animal |
| Family | IPR011907 | Ribonuclease III |
| Homologous_superfamily | IPR036389 | Ribonuclease III, endonuclease domain superfamily |
1 - 5 of 5
Domain Details Per Protein
| Protein | Additional Resources | Length | Double-stranded RNA-binding domain | Ribonuclease III | Ribonuclease III domain | Ribonuclease III, endonuclease domain superfamily | RNase III, double-stranded RNA binding domain, animal |
|---|---|---|---|---|---|---|---|
| UniProtKB:A2RV16 | InterPro | 1289 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
drosha-203
(1)
|
Ensembl | 5,132 nt | ||
| mRNA |
rnasen-201
(1)
|
Ensembl | 4,230 nt | ||
| ncRNA |
rnasen-002
(1)
|
Ensembl | 711 nt |
1 - 3 of 3
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-198P7 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7150667 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:158612 | ZFIN Curated Data |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001110472 (1) | 4157 nt | ||
| Genomic | GenBank:BX571950 (1) | 196442 nt | ||
| Polypeptide | UniProtKB:A2RV16 (1) | 1289 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | DROSHA | 5 | Functional complementation (1) |
- Zhang, X., Yang, F., Liu, F., Tian, Q., Hu, M., Li, P., Zeng, Y. (2022) Conservation of Differential Animal MicroRNA Processing by Drosha and Dicer. Frontiers in molecular biosciences. 8:730006
- Martínez, R., Tu, W., Eng, T., Allaire-Leung, M., Piña, B., Navarro-Martín, L., Mennigen, J.A. (2020) Acute and long-term metabolic consequences of early developmental Bisphenol A exposure in zebrafish (Danio rerio). Chemosphere. 256:127080
- Zhu, Z., Liu, Y., Xu, W., Liu, T., Xie, Y., Sham, K.W.Y., Sha, O., Cheng, C.H.K. (2020) Functional Characterization and Expression Analyses Show Differential Roles of Maternal and Zygotic Dgcr8 in Early Embryonic Development. Frontiers in genetics. 11:299
- Li, P., Tian, Q., Hu, M., Li, W., Zhang, X., Zeng, Y. (2019) Cloning, expression, and characterization of the zebrafish Dicer and Drosha enzymes. Biochemical and Biophysical Research Communications. 514(1):200-204
- Martinez, R., Vera-Chang, M.N., Haddad, M., Zon, J., Navarro-Martin, L., Trudeau, V.L., Mennigen, J.A. (2019) Developmental fluoxetine exposure in zebrafish reduces offspring basal cortisol concentration via life stage-dependent maternal transmission. PLoS One. 14:e0212577
- Jiang, X., Wooderchak-Donahue, W.L., McDonald, J., Ghatpande, P., Baalbaki, M., Sandoval, M., Hart, D., Clay, H., Coughlin, S., Lagna, G., Bayrak-Toydemir, P., Hata, A. (2018) Inactivating mutations in Drosha mediate vascular abnormalities similar to hereditary hemorrhagic telangiectasia. Science signaling. 11(513)
- White, R.J., Collins, J.E., Sealy, I.M., Wali, N., Dooley, C.M., Digby, Z., Stemple, D.L., Murphy, D.N., Billis, K., Hourlier, T., Füllgrabe, A., Davis, M.P., Enright, A.J., Busch-Nentwich, E.M. (2017) A high-resolution mRNA expression time course of embryonic development in zebrafish. eLIFE. 6
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- López-Bellido, R., Barreto-Valer, K., Sánchez-Simón, F.M., and Rodríguez, R.E. (2012) Cocaine Modulates the Expression of Opioid Receptors and miR-let-7d in Zebrafish Embryos. PLoS One. 7(11):e50885
1 - 10 of 14
Show