hs6st1b

ID

ZDB-GENE-070103-2

Name

heparan sulfate 6-O-sulfotransferase 1b

Symbol

hs6st1b Nomenclature History

Previous Names

6-ost-1b (1)

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable heparan sulfate 6-sulfotransferase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process, enzymatic modification. Predicted to be located in membrane. Is expressed in several structures, including hindbrain neural keel; immature eye; nervous system; pancreatic bud; and presumptive floor plate. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 15 with or without anosmia. Orthologous to human HS6ST1 (heparan sulfate 6-O-sulfotransferase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from Cadwallader et al., 2006

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hs6st1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hypogonadotropic hypogonadism 15 with or without anosmia	Alliance	{Hypogonadotropic hypogonadism 15 with or without anosmia}	614880

Associated With hs6st1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR005331	Sulfotransferase
Family	IPR010635	Heparan sulphate 6-sulfotransferase/Protein-tyrosine sulfotransferase
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase