Gene

pm20d1.2

ID

ZDB-GENE-061013-637

Name

peptidase M20 domain containing 1, tandem duplicate 2

Symbol

pm20d1.2 Nomenclature History

Previous Names

zgc:154035

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to enable hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides. Predicted to be involved in several processes, including adaptive thermogenesis; energy homeostasis; and regulation of oxidative phosphorylation uncoupler activity. Predicted to act upstream of or within proteolysis. Predicted to be located in extracellular space. Orthologous to human PM20D1 (peptidase M20 domain containing 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pm20d1.2 Human Ortholog

No data available

Associated With pm20d1.2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR011650	Peptidase M20, dimerisation domain
Family	IPR002933	Peptidase M20
Family	IPR017141	Peptidase M20, carboxypeptidase S
Family	IPR047177	Peptidase M20A
Homologous_superfamily	IPR036264	Bacterial exopeptidase dimerisation domain

Domain Details Per Protein

Protein	Length	Bacterial exopeptidase dimerisation domain	Peptidase M20	Peptidase M20A	Peptidase M20, carboxypeptidase S	Peptidase M20, dimerisation domain
UniProtKB:B2GT51 InterPro	522
UniProtKB:A0A8M9PKV1 InterPro	522
UniProtKB:Q08BB2 InterPro	522

Transcripts

Genome Browsers

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	pm20d1.2-201 (1) Ensembl	Ensembl		3,959 nt	Select Tool ZFIN BLAST
ncRNA	pm20d1.2-002 (1) Ensembl	Ensembl		489 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl
Note: Zebrafish genes pm20d1.1 and pm20d1.2 are likely tandem duplicates as they are next to each other in the genome, are similar, and not part of a gene family. Also, the amino acid sequence of both genes shows identity to single human PM20D1 and mouse Pm20d1 genes and is further supported by conserved location.

Citations