Gene

mark3b

ID

ZDB-GENE-060929-80

Name

MAP/microtubule affinity-regulating kinase 3b

Symbol

mark3b Nomenclature History

Previous Names

si:dkeyp-50f7.6
zgc:153725

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have protein serine/threonine kinase activity and tau-protein kinase activity. Predicted to be involved in intracellular signal transduction and microtubule cytoskeleton organization. Predicted to localize to cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in visual impairment and progressive phthisis bulbi. Orthologous to human MARK3 (microtubule affinity regulating kinase 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mark3b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
visual impairment and progressive phthisis bulbi	Alliance	?Visual impairment and progressive phthisis bulbi	618283

Associated With mark3b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR001772	Kinase associated domain 1 (KA1)
Domain	IPR015940	Ubiquitin-associated domain
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR028375	KA1 domain/Ssp2, C-terminal

Domain Details Per Protein

Protein	Length	KA1 domain/Ssp2, C-terminal	Kinase associated domain 1 (KA1)	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site	Ubiquitin-associated domain
UniProtKB:A0A8M3AL25 InterPro	834
UniProtKB:A0A8M3B4C1 InterPro	825
UniProtKB:A2CEF7 InterPro	754
UniProtKB:A0A8M3ALR5 InterPro	814
UniProtKB:A0A8M2BHK1 InterPro	765
UniProtKB:A0A8M2BHK8 InterPro	774

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mark3b-201 (1) Ensembl	Havana	4411 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	mark3b-203 (1) Ensembl	Havana	640 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	mark3b-002 (1) Ensembl	Havana	1263 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations