Gene

mtfmt

ID

ZDB-GENE-060929-120

Name

mitochondrial methionyl-tRNA formyltransferase

Symbol

mtfmt Nomenclature History

Previous Names

zgc:152651

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to enable methionyl-tRNA formyltransferase activity. Predicted to be involved in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA. Predicted to act upstream of or within translation. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 15 and nuclear type mitochondrial complex I deficiency 27. Orthologous to human MTFMT (mitochondrial methionyl-tRNA formyltransferase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mtfmt Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
combined oxidative phosphorylation deficiency 15	Alliance	Combined oxidative phosphorylation deficiency 15	614947
nuclear type mitochondrial complex I deficiency 27	Alliance	Mitochondrial complex I deficiency, nuclear type 27	618248

Associated With mtfmt Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002376	Formyl transferase, N-terminal
Domain	IPR005793	Formyl transferase, C-terminal
Domain	IPR041711	Methionyl-tRNA formyltransferase, N-terminal domain
Family	IPR005794	Methionyl-tRNA formyltransferase
Homologous_superfamily	IPR036477	Formyl transferase, N-terminal domain superfamily