Gene
ears2
- ID
- ZDB-GENE-060825-214
- Name
- glutamyl-tRNA synthetase 2, mitochondrial
- Symbol
- ears2 Nomenclature History
- Previous Names
-
- zgc:153247
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable glutamate-tRNA ligase activity. Predicted to be involved in glutamyl-tRNA aminoacylation. Predicted to act upstream of or within tRNA aminoacylation for protein translation. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 12. Orthologous to human EARS2 (glutamyl-tRNA synthetase 2, mitochondrial).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| combined oxidative phosphorylation deficiency 12 | Alliance | Combined oxidative phosphorylation deficiency 12 | 614924 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001412 | Aminoacyl-tRNA synthetase, class I, conserved site |
| Domain | IPR020058 | Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain |
| Domain | IPR033910 | Glutamyl-tRNA synthetase |
| Domain | IPR045462 | Aminoacyl-tRNA synthetase, class I, anticodon-binding |
| Family | IPR000924 | Glutamyl/glutaminyl-tRNA synthetase |
| Family | IPR004527 | Glutamate-tRNA ligase, bacterial/mitochondrial |
| Family | IPR049940 | Glutamyl-Q tRNA(Asp) synthetase/Glutamate--tRNA ligase |
| Homologous_superfamily | IPR008925 | Aminoacyl-tRNA synthetase, class I, anticodon-binding superfamily |
| Homologous_superfamily | IPR014729 | Rossmann-like alpha/beta/alpha sandwich fold |
| Homologous_superfamily | IPR020751 | Aminoacyl-tRNA synthetase, class I, anticodon-binding domain, subdomain 2 |
Domain Details Per Protein
| Protein | Length | Aminoacyl-tRNA synthetase, class I, anticodon-binding | Aminoacyl-tRNA synthetase, class I, anticodon-binding domain, subdomain 2 | Aminoacyl-tRNA synthetase, class I, anticodon-binding superfamily | Aminoacyl-tRNA synthetase, class I, conserved site | Glutamate-tRNA ligase, bacterial/mitochondrial | Glutamyl/glutaminyl-tRNA synthetase | Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain | Glutamyl-Q tRNA(Asp) synthetase/Glutamate--tRNA ligase | Glutamyl-tRNA synthetase | Rossmann-like alpha/beta/alpha sandwich fold |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9Q7R8
|
524 | ||||||||||
|
UniProtKB:Q0P499
|
503 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available