Gene

topbp1

ID
ZDB-GENE-060626-1
Name
DNA topoisomerase II binding protein 1
Symbol
topbp1 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Involved in cellular response to DNA damage stimulus; definitive hemopoiesis; and regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Localizes to nucleus. Is expressed in caudal fin and head. Orthologous to human TOPBP1 (DNA topoisomerase II binding protein 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Gao et al., 2015
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Gao et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With topbp1 Human Ortholog
No data available
Associated With topbp1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001357 BRCT domain
Domain IPR044737 TopBP1, first BRCT domain
Homologous_superfamily IPR036420 BRCT domain superfamily
Domain Details Per Protein
Protein Length BRCT domain BRCT domain superfamily TopBP1, first BRCT domain
UniProtKB:F1R135 1520
UniProtKB:A0A2R8RVN3 1526
UniProtKB:A0A8M6YVL2 1519
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations