ZFIN is now using GRCz12tu for Genomic Data
Gene
srgap3
- ID
- ZDB-GENE-060524-4
- Name
- SLIT-ROBO Rho GTPase activating protein 3
- Symbol
- srgap3 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to be involved in negative regulation of cell migration. Predicted to act upstream of or within signal transduction. Predicted to be active in cytoplasm. Orthologous to human SRGAP3 (SLIT-ROBO Rho GTPase activating protein 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Zheng et al., 2022
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from van Dam et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000198 | Rho GTPase-activating protein domain |
| Domain | IPR001060 | FCH domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR031160 | F-BAR domain |
| Domain | IPR035648 | srGAP1/2/3, SH3 domain |
| Family | IPR051627 | SLIT-ROBO Rho GTPase-activating |
| Homologous_superfamily | IPR008936 | Rho GTPase activation protein |
| Homologous_superfamily | IPR027267 | AH/BAR domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | AH/BAR domain superfamily | F-BAR domain | FCH domain | Rho GTPase-activating protein domain | Rho GTPase activation protein | SH3 domain | SH3-like domain superfamily | SLIT-ROBO Rho GTPase-activating | srGAP1/2/3, SH3 domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IAE2 | InterPro | 1094 | |||||||||
| UniProtKB:E7EYC8 | InterPro | 1070 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
srgap3-201
(1)
|
Ensembl | 5,100 nt | ||
| mRNA |
srgap3-205
(1)
|
Ensembl | 4,197 nt | ||
| ncRNA |
srgap3-002
(1)
|
Ensembl | 881 nt | ||
| ncRNA |
srgap3-003
(1)
|
Ensembl | 468 nt | ||
| ncRNA |
srgap3-004
(1)
|
Ensembl | 539 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers